Abdalla Abualgasim Elgaili, Duan Xiangke, Deng Wanyan, Zeng Jie, Xie Jianping
Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, Key Laboratory of Eco-environments in Three Gorges Reservoir Region, Ministry of Education, School of Life Sciences, Southwest University, Beibei, Chongqing 400715, China; Department of Clinical Microbiology, College of Medical Laboratory Sciences, Omdurman Islamic University, Omdurman, Khartoum, Sudan.
Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, Key Laboratory of Eco-environments in Three Gorges Reservoir Region, Ministry of Education, School of Life Sciences, Southwest University, Beibei, Chongqing 400715, China.
Infect Genet Evol. 2016 Nov;45:378-382. doi: 10.1016/j.meegid.2016.09.023. Epub 2016 Sep 28.
Macrophages are crucial player in the defense against multiple intracellular pathogens. Mycobacterium tuberculosis, the causative agent of tuberculosis which inflicted around one third of global population, can replicate and persist within macrophages. MicroRNAs, endogenous, small noncoding RNA, can regulate the expression of macrophages genes required for appropriate signaling. Mycobacteria can manipulate the expression of macrophages microRNAs to subvert cell response for its survival and persistence. This review summarized the progress of microRNAs in mycobacterial pathogenesis.
巨噬细胞是抵御多种细胞内病原体的关键参与者。结核分枝杆菌是结核病的病原体，全球约三分之一的人口受到其影响，它可在巨噬细胞内复制并持续存在。微小RNA是内源性的小非编码RNA，可调节巨噬细胞中适当信号传导所需基因的表达。分枝杆菌可操纵巨噬细胞微小RNA的表达，以颠覆细胞反应来实现其生存和持续存在。本综述总结了微小RNA在分枝杆菌致病机制方面的研究进展。
