Pokorn Marko, Jevšnik Monika, Petrovec Miroslav, Steyer Andrej, Mrvič Tatjana, Grosek Štefan, Lusa Lara, Strle Franc
1 Department of Infectious Diseases, University Medical Centre Ljubljana, Ljubljana, Slovenia.
2 Institute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
J Child Neurol. 2017 Jan;32(1):84-93. doi: 10.1177/0883073816670820. Epub 2016 Oct 3.
The majority of children with febrile seizures have viral infections and viruses were detected in 22% to 63% of children in published studies. Using molecular methods, viruses were also detected in asymptomatic persons. A prospective study was conducted to detect respiratory and enteric viruses in 192 children with febrile seizures and compare the detection rates to those found in 156 healthy age-matched controls. A respiratory or enteric virus was detected in 72.9% of children with febrile seizures and in 51.4% of healthy controls. The viruses most strongly associated with febrile seizures were influenza, respiratory syncytial virus, parainfluenza, human coronavirus, and rotavirus. Compared to healthy controls, the age-adjusted odds ratios for nasopharynx virus positivity in febrile seizure patients were 79.4, 2.8, 7.2, and 4.9 for influenza virus, parainfluenza virus, respiratory syncytial virus, and human coronavirus, respectively, and 22.0 for rotavirus in stool. The detected virus did not influence clinical features of febrile seizure.
大多数热性惊厥儿童患有病毒感染，在已发表的研究中，22%至63%的儿童检测到病毒。使用分子方法，在无症状者中也检测到了病毒。进行了一项前瞻性研究，以检测192例热性惊厥儿童的呼吸道和肠道病毒，并将检测率与156例年龄匹配的健康对照者进行比较。72.9%的热性惊厥儿童和51.4%的健康对照者检测到呼吸道或肠道病毒。与热性惊厥最密切相关的病毒是流感病毒、呼吸道合胞病毒、副流感病毒、人冠状病毒和轮状病毒。与健康对照者相比，热性惊厥患者鼻咽部病毒阳性的年龄调整比值比，流感病毒、副流感病毒、呼吸道合胞病毒和人冠状病毒分别为79.4、2.8、7.2和4.9，粪便中轮状病毒为22.0。检测到的病毒不影响热性惊厥的临床特征。
