Sayili Ayse, Ozkan Aysegul Taylan, Schallig Henk D F H
Department of Pediatrics, Dr. Burhan Nalbantoglu Governmental Hospital, Nicosia, Cyprus.
Department of Medical Microbiology and Clinic Microbiology, Faculty of Medicine, Near East University, Nicosia, Cyprus.
Am J Trop Med Hyg. 2016 Dec 7;95(6):1386-1388. doi: 10.4269/ajtmh.16-0511. Epub 2016 Oct 3.
Visceral leishmaniasis (VL) is a vector-borne disease widespread in the Mediterranean basin, including Cyprus. During the last decades no cases were notified from northern Cyprus, but herein three cases of VL (female: 2, male: 1, median age: 24.6 months) diagnosed during their hospital admission between January 2011 and December 2012 are reported. Diagnosis was based on clinical findings; 1 ≥ 1/64 titer positivity of immunofluorescence antibodies, Leishmania amastigotes in Giemsa-stained slides of bone marrow, as well as molecular identification confirmed that in all three the infecting pathogen was Leishmania infantum Fever, splenomegaly, and hepatomegaly were the typical clinical findings. First-line treatment with liposomal amphotericin B (AmBisome; intravenous, 3 mg/kg) on days 1-5, followed by the same on days 10 and 21 yielded a successful outcome with no relapse in all cases. These confirmed VL cases found within 2 years demonstrate the presence of VL on the island.
内脏利什曼病（VL）是一种通过媒介传播的疾病，在地中海盆地（包括塞浦路斯）广泛流行。在过去几十年中，北塞浦路斯未报告过病例，但本文报告了2011年1月至2012年12月期间在医院收治的3例VL病例（女性：2例，男性：1例，中位年龄：24.6个月）。诊断基于临床症状；免疫荧光抗体滴度≥1/64阳性、吉姆萨染色骨髓涂片中有利什曼原虫无鞭毛体，以及分子鉴定证实所有3例感染病原体均为婴儿利什曼原虫。发热、脾肿大和肝肿大是典型的临床症状。在第1 - 5天使用脂质体两性霉素B（安必素；静脉注射，3 mg/kg）进行一线治疗，随后在第10天和第21天重复治疗，所有病例均取得成功结果且无复发。在2年内发现的这些确诊VL病例证明该岛存在VL。
