Department of Medicine, Cancer Center, Howard University Cancer Center, Howard University Hospital, Rm #320, 2041 Georgia Ave., Washington, DC 20059, USA.
Dig Dis Sci. 2012 Nov;57(11):2924-8. doi: 10.1007/s10620-012-2349-3. Epub 2012 Sep 26.
Negative association has been reported between presence of Helicobacter pylori and developing gastroesophageal reflux disease (GERD) and its complications. The aim of this study was to determine whether H. pylori (HP) can be protective against GERD in an African American (AA) population.
From 2004 to 2007, we studied 2,020 cases; esophagitis (58), gastritis (1,558), both esophagitis and gastritis (363) and a normal control group (41). We collected their pathology and endoscopy unit reports. HP status was determined based on staining of gastric biopsy.
HP data was available for 79 % (1,611) of the cases. The frequency of HP positivity in gastritis patients was 40 % (506), in esophagitis patients 4 % and in normal controls 34 % (11), while HP was positive in 34 % of the patients with both esophagitis and gastritis. After adjusting for effects of age and sex, odds ratio of HP was 0.06 (95 % CI 0.01-0.59; P value = 0.01) for the esophagitis group versus the normal group.
Our results show H. pylori has a significant negative association with esophagitis in AAs which may point to a protective role of H. pylori in the pathogenesis of esophagitis. In addition, H. pylori may be the reason for the low GERD complications in AAs.
已有研究报道，幽门螺杆菌（H. pylori）的存在与胃食管反流病（GERD）及其并发症的发生呈负相关。本研究旨在确定 H. pylori 是否可以对非裔美国人（AA）群体的 GERD 起到保护作用。
2004 年至 2007 年，我们研究了 2020 例病例，包括食管炎（58 例）、胃炎（1558 例）、食管炎和胃炎并存（363 例）和正常对照组（41 例）。我们收集了他们的病理学和内镜检查报告。根据胃活检的染色来确定 H. pylori 状态。
79%（1611 例）的病例可获得 H. pylori 数据。胃炎患者 H. pylori 阳性率为 40%（506 例），食管炎患者为 4%，正常对照组为 34%（11 例），而食管炎和胃炎并存的患者中 H. pylori 阳性率为 34%。调整年龄和性别影响后，与正常对照组相比，食管炎组 H. pylori 的比值比为 0.06（95%CI 0.01-0.59；P 值=0.01）。
我们的研究结果表明，H. pylori 与非裔美国人的食管炎有显著的负相关，这可能表明 H. pylori 在食管炎发病机制中起保护作用。此外，H. pylori 可能是非裔美国人 GERD 并发症发生率低的原因。
