Chen Ziming, Chen Yuchan, Huang Hongbo, Yang Hongyan, Zhang Weimin, Sun Yulin, Wen Jing
School of Chemistry and Chemical Engineering, Lingnan Normal University, 29# Cunjin Road, Zhanjiang 524048, China, Tel./Fax: +86-075-9318-3245.
State Key Laboratory of Applied Microbiology Southern China, Guangdong Institute of Microbiology, 100 Central Xianlie Road, Guangzhou 510070, China.
Z Naturforsch C J Biosci. 2017 Mar 1;72(3-4):129-132. doi: 10.1515/znc-2016-0122.
A new cytochalasin, named cytochalasin P1 (1), together with four known analogs (2-5) was isolated from marine-derived fungus Xylaria sp. SOF11 from the South China Sea. The structure of the new compound was elucidated on the basis of MS and NMR (1H, 13C, HSQC, HMBC, and NOESY) data analyses. Compounds 1-5 were tested for their cytotoxicities against four tumor cell lines (SF-268, MCF-7, NCI-H460, and HepG-2). Compounds 1-5 showed significant cytotoxicity against two tumor cell lines MCF-7 and SF-268, with the IC50 values varying between 0.33 and 4.17 μM.
从中国南海海洋来源的真菌木层孔菌属SOF11中分离出一种新的细胞松弛素，命名为细胞松弛素P1（1），以及四种已知类似物（2 - 5）。通过质谱和核磁共振（1H、13C、HSQC、HMBC和NOESY）数据分析阐明了新化合物的结构。测试了化合物1 - 5对四种肿瘤细胞系（SF - 268、MCF - 7、NCI - H460和HepG - 2）的细胞毒性。化合物1 - 5对两种肿瘤细胞系MCF - 7和SF - 268显示出显著的细胞毒性，IC50值在0.33至4.17μM之间变化。
