内布拉斯加红：一种用于化学生物学应用的基于次膦酸盐的近红外荧光团支架。
Nebraska Red: a phosphinate-based near-infrared fluorophore scaffold for chemical biology applications.
作者信息
Zhou Xinqi, Lai Rui, Beck Jon R, Li Hui, Stains Cliff I
机构信息
Department of Chemistry, University of Nebraska-Lincoln, Lincoln, NE 68588, USA.
出版信息
Chem Commun (Camb). 2016 Oct 11;52(83):12290-12293. doi: 10.1039/c6cc05717a.
Abstract
A series of novel phosphinate-based dyes displaying near-infrared fluorescence (NIR) are reported. These dyes exhibit remarkable photostability and brightness. The phosphinate functionality is leveraged as an additional reactive handle in order to tune cell permeability as well as provide a proof-of-principle for a self-reporting small molecule delivery vehicle.
摘要
报道了一系列显示近红外荧光（NIR）的新型次膦酸酯基染料。这些染料表现出卓越的光稳定性和亮度。利用次膦酸酯官能团作为额外的反应性基团，以调节细胞通透性，并为自我报告的小分子递送载体提供原理验证。
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