利用具有原位网络形成能力的可注射水凝胶调控干细胞分泌组
Regulating Stem Cell Secretome Using Injectable Hydrogels with In Situ Network Formation.
作者信息
Cai Lei, Dewi Ruby E, Goldstone Andrew B, Cohen Jeffrey E, Steele Amanda N, Woo Y Joseph, Heilshorn Sarah C
机构信息
Department of Materials Science and Engineering, Stanford Neuroscience Institute, Stanford University, Stanford, CA, 94305, USA.
Department of Materials Science and Engineering, Stanford University, Stanford, CA, 94305, USA.
出版信息
Adv Healthc Mater. 2016 Nov;5(21):2758-2764. doi: 10.1002/adhm.201600497. Epub 2016 Oct 6.
Abstract
A family of shear-thinning hydrogels for injectable encapsulation and long-term delivery (SHIELD) has been designed and synthesized with controlled in situ stiffening properties to regulate the stem cell secretome. The authors demonstrate that SHIELD with an intermediate stiffness (200-400 Pa) could significantly promote the angiogenic potential of human adipose-derived stem cells.
摘要
已设计并合成了一种用于可注射封装和长期递送的剪切稀化水凝胶家族（SHIELD），其具有可控的原位硬化特性，以调节干细胞分泌组。作者证明，具有中等硬度（200 - 400帕斯卡）的SHIELD可显著促进人脂肪来源干细胞的血管生成潜力。
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