利用光学微血管造影术对冠状动脉微血管进行深度分辨三维可视化。
Depth-resolved 3D visualization of coronary microvasculature with optical microangiography.
作者信息
Qin Wan, Roberts Meredith A, Qi Xiaoli, Murry Charles E, Zheng Ying, Wang Ruikang K
机构信息
Department of Bioengineering, University of Washington, Seattle, WA 98195, USA.
出版信息
Phys Med Biol. 2016 Nov 7;61(21):7536-7550. doi: 10.1088/0031-9155/61/21/7536. Epub 2016 Oct 7.
Abstract
In this study, we propose a novel implementation of optical coherence tomography-based angiography combined with ex vivo perfusion of fixed hearts to visualize coronary microvascular structure and function. The extracorporeal perfusion of Intralipid solution allows depth-resolved angiographic imaging, control of perfusion pressure, and high-resolution optical microangiography. The imaging technique offers new opportunities for microcirculation research in the heart, which has been challenging due to motion artifacts and the lack of independent control of pressure and flow. With the ability to precisely quantify structural and functional features, this imaging platform has broad potential for the study of the pathophysiology of microvasculature in the heart as well as other organs.
摘要
在本研究中，我们提出了一种基于光学相干断层扫描血管造影术的新颖实现方法，该方法结合固定心脏的离体灌注，以可视化冠状动脉微血管结构和功能。脂质乳剂溶液的体外灌注可实现深度分辨血管造影成像、灌注压力控制和高分辨率光学微血管造影。该成像技术为心脏微循环研究提供了新机会，由于运动伪影以及缺乏对压力和流量的独立控制，心脏微循环研究一直具有挑战性。凭借精确量化结构和功能特征的能力，该成像平台在研究心脏以及其他器官微血管系统的病理生理学方面具有广阔的潜力。
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