T 淋巴细胞衰老：增强人类免疫力的意义。

Senescence of T Lymphocytes: Implications for Enhancing Human Immunity.

机构信息

Division of Infection and Immunity, University College London, London, UK.

William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.

出版信息

Trends Immunol. 2016 Dec;37(12):866-876. doi: 10.1016/j.it.2016.09.002. Epub 2016 Oct 4.

DOI:10.1016/j.it.2016.09.002

PMID:27720177

Abstract

As humans live longer, a central concern is to find ways to maintain their health as they age. Immunity declines during ageing, as shown by the increased susceptibility to infection by both previously encountered and new pathogens and by the decreased efficacy of vaccination. It is therefore crucial to understand the mechanisms responsible for this decrease in immunity and to develop new strategies to enhance immune function in older humans. We discuss here how the induction of senescence alters leukocyte, and specifically T cell, function. An emerging concept is that senescence and nutrient sensing-signalling pathways within T cells converge to regulate functional responses, and the manipulation of these pathways may offer new ways to enhance immunity during ageing.

摘要

随着人类寿命的延长，人们越来越关注如何在衰老过程中保持健康。随着年龄的增长，免疫力会下降，这表现为对以前遇到过的和新出现的病原体的易感性增加，以及疫苗接种效果降低。因此，了解导致这种免疫下降的机制并开发新的策略来增强老年人的免疫功能至关重要。我们在这里讨论诱导衰老如何改变白细胞，特别是 T 细胞的功能。一个新出现的概念是，T 细胞中的衰老和营养感应信号通路汇聚在一起调节功能反应，而对这些通路的操纵可能为衰老过程中增强免疫力提供新的途径。