老年人群中氧化甾醇与轻度认知障碍的关系：一项病例对照研究。
Relationship between oxysterols and mild cognitive impairment in the elderly: a case-control study.
作者信息
Liu Quanri, An Yu, Yu Huanling, Lu Yanhui, Feng Lingli, Wang Chao, Xiao Rong
机构信息
School of Public Health, Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, No.10 Xitoutiao, You An Men Wai, Beijing, 100069, Fengtai District, China.
出版信息
Lipids Health Dis. 2016 Oct 10;15(1):177. doi: 10.1186/s12944-016-0344-y.
BACKGROUND
To investigate the relationship between oxysterols and mild cognitive impairment (MCI) in a matched case-control study.
METHODS
The plasma levels of four oxysterols, 27-hydroxycholesterol (27-OHC), 24S-hydroxycholesterol (24S-OHC), 7α-hydroxycholesterol (7α-OHC) and 7β-hydroxycholesterol (7β-OHC), were analyzed by High Performance Liquid Chromatography-Mass Spectrometry (HPLC-MS) and compared between 70 MCI patients and 140 matched controls with normal cognition. The odds ratio (OR) was calculated using logistic analyses to assess the association between oxysterols and MCI.
RESULTS
Compared with controls with normal cognition, plasma level of 27-OHC was significantly higher in MCI patients. Logistic analyses suggested high plasma level of 27-OHC was significantly associated with MCI even after multivariate adjustment (OR = 2.86, 95 % CI: 1.52 ~ 5.37).
CONCLUSIONS
Our findings suggested that the increased plasma level of 27-OHC was associated with MCI, suggesting high plasma levels of 27-OHC may pay an important role in the development of MCI.
背景
在一项匹配的病例对照研究中，调查氧化甾醇与轻度认知障碍（MCI）之间的关系。
方法
采用高效液相色谱-质谱联用（HPLC-MS）分析70例MCI患者和140例认知正常的匹配对照者血浆中4种氧化甾醇，即27-羟基胆固醇（27-OHC）、24S-羟基胆固醇（24S-OHC）、7α-羟基胆固醇（7α-OHC）和7β-羟基胆固醇（7β-OHC）的水平，并进行比较。采用逻辑分析计算比值比（OR），以评估氧化甾醇与MCI之间的关联。
结果
与认知正常的对照者相比，MCI患者血浆中27-OHC水平显著升高。逻辑分析表明，即使经过多变量调整，血浆中27-OHC水平升高仍与MCI显著相关（OR = 2.86，95%CI：1.52～5.37）。
结论
我们的研究结果表明，血浆中27-OHC水平升高与MCI有关，提示血浆中高水平的27-OHC可能在MCI的发生发展中起重要作用。
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