Wright Gavin, Swain Mark, Annane Djillali, Saliba Faouzi, Samuel Didier, Arroyo Vicente, DeMorrow Sharon, Witt Anne
Gastroenterology Department, Basildon & Thurrock University Hospitals, Basildon, UK.
Hepatology and Hepatobiliary Medicine, The Royal Free Hospital, Pond Street, London, NW3 2QG, UK.
Metab Brain Dis. 2016 Dec;31(6):1339-1354. doi: 10.1007/s11011-016-9918-7. Epub 2016 Oct 11.
At the recent ISHEN ('International Symposium of Hepatic Encephalopathy & Nitrogen Metabolism') conference in London, a whole session was dedicated to our increasing awareness of the importance of inflammation in the brain - termed 'neuroinflammation', in the development of Hepatic Encephalopathy (HE) - the neurological manifestations of advanced liver disease. In this review our ISHEN speakers further discuss the content of their sessional presentations and more broadly we discuss our understanding of the role of neuroinflammation in HE pathogenesis.
在最近于伦敦举行的国际肝性脑病与氮代谢研讨会(ISHEN)上,有整整一场会议专门探讨了我们对炎症在大脑中(称为“神经炎症”)在肝性脑病(HE)——晚期肝病的神经表现——发展过程中的重要性的认识不断提高的情况。在这篇综述中,ISHEN的发言者们进一步讨论了他们会议发言的内容,更广泛地说,我们也讨论了我们对神经炎症在肝性脑病发病机制中作用的理解。