Borghi F, Sevá-Pessôa B, Grassi-Kassisse D M
LABEEST - Laboratory of Stress Study, Department of Structural and Functional Biology. Institute of Biology, University of Campinas - UNICAMP, CEP: 13083-862, Campinas, SP, Brazil.
Laboratory of Kidney and Hormones, Department of Medicine, Nephrology Division, Escola Paulista de Medicina, Universidade Federal de São Paulo, Rua Botucatu, 740, CEP: 04023-900, São Paulo, SP, Brazil.
Cell Tissue Res. 2016 Dec;366(3):543-548. doi: 10.1007/s00441-016-2515-6. Epub 2016 Oct 12.
Cardiometabolic diseases are linked to a cluster of modifiable factors, including risk factors closely related to central adiposity. Chronic renin-angiotensin-aldosterone system (RAAS) activation has far-reaching effects on cardiometabolic risk and is a substantial contributor to this clinical condition. RAAS components are locally expressed in the vessels and adipose tissue. This review appoints RAAS, through the classical and the alternative view, as the main mediator of the cross-talk in cardiometabolic syndrome.
心血管代谢疾病与一系列可改变的因素相关，包括与中心性肥胖密切相关的危险因素。慢性肾素-血管紧张素-醛固酮系统（RAAS）激活对心血管代谢风险具有深远影响，并且是导致这种临床状况的一个重要因素。RAAS成分在血管和脂肪组织中局部表达。本综述通过经典观点和另一种观点，将RAAS认定为心血管代谢综合征中相互作用的主要介导因素。
