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脂肪组织肾素-血管紧张素-醛固酮系统信号与肥胖相关性高血压之间的联系。

The Link Between Adipose Tissue Renin-Angiotensin-Aldosterone System Signaling and Obesity-Associated Hypertension.

机构信息

Department of Internal Medicine and Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, Maastricht, The Netherlands.

Department of Internal Medicine and Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, Maastricht, The Netherlands

出版信息

Physiology (Bethesda). 2017 May;32(3):197-209. doi: 10.1152/physiol.00037.2016.

DOI:10.1152/physiol.00037.2016
PMID:28404736
Abstract

Obese individuals frequently develop hypertension, which is for an important part attributable to renin-angiotensin-aldosterone system (RAAS) overactivity. This review summarizes preclinical and clinical evidence on the involvement of dysfunctional adipose tissue in RAAS activation and on the renal, central, and vascular mechanisms linking RAAS components to obesity-associated hypertension.

摘要

肥胖个体常发生高血压，其中一个重要原因是肾素-血管紧张素-醛固酮系统（RAAS）过度活跃。这篇综述总结了关于功能失调的脂肪组织在 RAAS 激活中的作用，以及 RAAS 成分与肥胖相关高血压之间的肾脏、中枢和血管机制的临床前和临床证据。

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