Han Yanqi, Sun Qianwen, Chen Wei, Gao Yue, Ye Jun, Chen Yanmin, Wang Tingting, Gao Lili, Liu Yuling, Yang Yanfang
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100050, China.
Beijing Key laboratory of Drug Delivery Technology and Novel Formulation, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100050, China.
J Pharm Anal. 2024 May;14(5):100913. doi: 10.1016/j.jpha.2023.12.003. Epub 2023 Dec 13.
Obesity and related metabolic syndromes have been recognized as important disease risks, in which the role of adipokines cannot be ignored. Adiponectin (ADP) is one of the key adipokines with various beneficial effects, including improving glucose and lipid metabolism, enhancing insulin sensitivity, reducing oxidative stress and inflammation, promoting ceramides degradation, and stimulating adipose tissue vascularity. Based on those, it can serve as a positive regulator in many metabolic syndromes, such as type 2 diabetes (T2D), cardiovascular diseases, non-alcoholic fatty liver disease (NAFLD), sarcopenia, neurodegenerative diseases, and certain cancers. Therefore, a promising therapeutic approach for treating various metabolic diseases may involve elevating ADP levels or activating ADP receptors. The modulation of ADP genes, multimerization, and secretion covers the main processes of ADP generation, providing a comprehensive orientation for the development of more appropriate therapeutic strategies. In order to have a deeper understanding of ADP, this paper will provide an all-encompassing review of ADP.
肥胖及相关代谢综合征已被公认为重要的疾病风险因素，其中脂肪因子的作用不容忽视。脂联素（ADP）是关键的脂肪因子之一，具有多种有益作用，包括改善糖脂代谢、增强胰岛素敏感性、减轻氧化应激和炎症、促进神经酰胺降解以及刺激脂肪组织血管生成。基于这些作用，它可作为多种代谢综合征的正向调节因子，如2型糖尿病（T2D）、心血管疾病、非酒精性脂肪性肝病（NAFLD）、肌肉减少症、神经退行性疾病和某些癌症。因此，一种有前景的治疗各种代谢疾病的方法可能涉及提高ADP水平或激活ADP受体。ADP基因的调控、多聚化和分泌涵盖了ADP产生的主要过程，为开发更合适的治疗策略提供了全面的方向。为了更深入地了解ADP，本文将对ADP进行全面综述。
