2015年，在塞拉利昂弗里敦杂志码头地区传播的埃博拉病毒株的基因型异常。
Genotypic anomaly in Ebola virus strains circulating in Magazine Wharf area, Freetown, Sierra Leone, 2015.
作者信息
Smits Saskia L, Pas Suzan D, Reusken Chantal B, Haagmans Bart L, Pertile Peirro, Cancedda Corrado, Dierberg Kerry, Wurie Isata, Kamara Abdul, Kargbo David, Caddy Sarah L, Arias Armando, Thorne Lucy, Lu Jia, Jah Umaru, Goodfellow Ian, Koopmans Marion P
机构信息
Department of Viroscience, Erasmus Medical Center, Rotterdam, Netherlands.
出版信息
Euro Surveill. 2015;20(40). doi: 10.2807/1560-7917.ES.2015.20.40.30035.
Abstract
The Magazine Wharf area, Freetown, Sierra Leone was a focus of ongoing Ebola virus transmission from late June 2015. Viral genomes linked to this area contain a series of 13 T to C substitutions in a 150 base pair intergenic region downstream of viral protein 40 open reading frame, similar to the Ebolavirus/H.sapiens-wt/SLE/2014/Makona-J0169 strain (J0169) detected in the same town in November 2014. This suggests that recently circulating viruses from Freetown descend from a J0169-like virus.
摘要
2015年6月下旬起，塞拉利昂弗里敦的杂志码头地区成为埃博拉病毒持续传播的一个焦点。与该地区相关的病毒基因组在病毒蛋白40开放阅读框下游的一个150个碱基对的基因间隔区含有一系列13个从T到C的替换，这与2014年11月在同一城镇检测到的埃博拉病毒/H.sapiens-wt/SLE/2014/Makona-J0169毒株（J0169）相似。这表明弗里敦近期传播的病毒源自一种类似J0169的病毒。
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