Önger Mehmet Emin, Delibaş Burcu, Türkmen Aysın Pınar, Erener Erkan, Altunkaynak Berrin Zuhal, Kaplan Süleyman
Department of Histology and Embryology, Faculty of Medicine, Ondokuz Mayis University.
Drug Discov Ther. 2017 Jan 15;10(6):285-291. doi: 10.5582/ddt.2016.01058. Epub 2016 Oct 17.
Nerve injuries result in functional loss in the innervated organ or body parts, and recovery is difficult unless surgical treatment has been done. Different surgical treatments have been suggested for nerve repair. Tissue engineering related to growth factors has arisen as an alternative approach for triggering and improving nerve regeneration. Therefore, the aim of this review is to provide a comprehensive analysis related to growth factors as tools for optimizing the regeneration process. Studies and reviews on the use of growth factors for nerve regeneration were compiled over the course of the review. According to literature review, it may be concluded that growth factors from different sources present promising treatment related to nerve regeneration involved in neuronal differentiation, greater myelination and axonal growth and proliferation of specific cells for nerve repair.
神经损伤会导致受其支配的器官或身体部位功能丧失，除非进行手术治疗，否则恢复困难。针对神经修复，人们提出了不同的手术治疗方法。与生长因子相关的组织工程学已成为触发和促进神经再生的一种替代方法。因此，本综述的目的是对生长因子作为优化再生过程的工具进行全面分析。在综述过程中，收集了关于使用生长因子促进神经再生的研究和综述。根据文献综述，可以得出结论，不同来源的生长因子在神经再生方面具有广阔的治疗前景，它们参与神经元分化、促进髓鞘形成以及轴突生长和特定神经修复细胞的增殖。
