Bodelón Oscar G, Clemente Celia, Alobera Miguel Angel, Aguado-Henche Soledad, Escudero María Lorenza, Alonso María Cristina García
Department of Characterization, Quality and Safety, Institute of Food Science, Technology and Nutrition (ICTAN-CSIC), Madrid, Spain.
Department of Human Anatomy and Embryology, School of Medicine, University of Alcalá, Alcalá de Henares, Spain.
Int J Implant Dent. 2016 Dec;2(1):18. doi: 10.1186/s40729-016-0051-5. Epub 2016 Jul 21.
In this work, the effect of the heat treatment on Ti6Al4V implants and topical administration of growth hormone to address a better osseointegration in osteoporotic patients has been analysed.
The osseointegration process of Ti6Al4V implants modified by oxidation treatment at 700 °C for 1 h and the influence of local administration of growth hormone (GH) in osteoporotic female rabbits after 15 and 30 days of implantation have been studied. Bone response was analysed through densitometric and histomorphometric studies. Characterization of the surface was provided by scanning electron microscopy.
The oxidation treatment promotes the formation of an oxide scale grown on the Ti6Al4V implants that alters the nanoroughness of the surface. Bone mineral density (BMD) increases from 0.347 ± 0.014 (commercial) to 0.383 ± 0.012 g cm-2 (modified), and bone-to-implant contact (BIC) goes from 48.01 ± 14.78 (commercial) to 55.37 ± 15.31 (modified) after 30 days of implantation.
The oxidation treatment on the Ti6Al4V dental implants enhances the early bone formation at the longest periods of implantation. No significant differences in the BMD and BIC results in healthy and osteoporotic rabbits were revealed with respect to the local administration of GH in the implantation site.
在本研究中，分析了热处理对钛6铝4钒（Ti6Al4V）植入物的影响以及局部应用生长激素对改善骨质疏松患者骨整合的作用。
研究了在700℃下氧化处理1小时对Ti6Al4V植入物骨整合过程的影响，以及在植入15天和30天后局部应用生长激素（GH）对骨质疏松雌性兔的影响。通过骨密度测量和组织形态计量学研究分析骨反应。通过扫描电子显微镜对表面进行表征。
氧化处理促进了在Ti6Al4V植入物上生长的氧化膜的形成，这改变了表面的纳米粗糙度。植入30天后，骨矿物质密度（BMD）从0.347±0.014（商用）增加到0.383±0.012 g/cm²（改性），骨与植入物的接触（BIC）从48.01±14.78（商用）增加到55.37±15.31（改性）。
对Ti6Al4V牙种植体进行氧化处理可在最长植入期增强早期骨形成。关于在植入部位局部应用GH，在健康兔和骨质疏松兔的BMD和BIC结果中未发现显著差异。
