静脉注射氨茶碱对特发性震颤的影响。
The effect of intravenous aminophylline on essential tremor.
作者信息
Buss D C, Marshall R W, Milligan N, McQueen I, Compston D A, Routledge P A
机构信息
Department of Pharmacology, University of Wales College of Medicine, Heath Park, Cardiff, UK.
出版信息
Br J Clin Pharmacol. 1997 Jan;43(1):119-21. doi: 10.1111/j.1365-2125.1997.tb00044.x.
AIMS
The effects of intravenous aminophylline (375 mg) or placebo (saline) were studied in 10 patients with benign essential tremor.
METHODS
This was a single-blind crossover study. Patients received aminophylline by i.v. infusion over 15 min or saline at least 1 week apart. Tremor was measured by a peizoresistive accelerometer at 15 min intervals predose and up to 2 h. Plasma theophylline concentrations were measured by h.p.l.c.
RESULTS
Tremor power was significantly greater following aminophylline (5.67-6.2 Hz) than placebo (5.6-5.9 Hz).
CONCLUSIONS
We conclude that intravenous aminophylline potentiates benign essential tremor when given acutely by the intravenous route in the doses required to achieve therapeutic benefits in asthma.
目的
对10例良性特发性震颤患者研究静脉注射氨茶碱（375毫克）或安慰剂（生理盐水）的效果。
方法
这是一项单盲交叉研究。患者接受静脉输注氨茶碱15分钟或生理盐水，间隔至少1周。在给药前及给药后长达2小时期间，每隔15分钟用压阻式加速度计测量震颤情况。采用高效液相色谱法测定血浆茶碱浓度。
结果
氨茶碱（5.67 - 6.2赫兹）治疗后震颤功率显著高于安慰剂（5.6 - 5.9赫兹）。
结论
我们得出结论，静脉注射氨茶碱在以治疗哮喘所需剂量急性静脉给药时会增强良性特发性震颤。
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