Buss D C, Marshall R W, Milligan N, McQueen I, Compston D A, Routledge P A
Department of Pharmacology, University of Wales College of Medicine, Heath Park, Cardiff, UK.
Br J Clin Pharmacol. 1997 Jan;43(1):119-21. doi: 10.1111/j.1365-2125.1997.tb00044.x.
The effects of intravenous aminophylline (375 mg) or placebo (saline) were studied in 10 patients with benign essential tremor.
This was a single-blind crossover study. Patients received aminophylline by i.v. infusion over 15 min or saline at least 1 week apart. Tremor was measured by a peizoresistive accelerometer at 15 min intervals predose and up to 2 h. Plasma theophylline concentrations were measured by h.p.l.c.
Tremor power was significantly greater following aminophylline (5.67-6.2 Hz) than placebo (5.6-5.9 Hz).
We conclude that intravenous aminophylline potentiates benign essential tremor when given acutely by the intravenous route in the doses required to achieve therapeutic benefits in asthma.
对10例良性特发性震颤患者研究静脉注射氨茶碱（375毫克）或安慰剂（生理盐水）的效果。
这是一项单盲交叉研究。患者接受静脉输注氨茶碱15分钟或生理盐水，间隔至少1周。在给药前及给药后长达2小时期间，每隔15分钟用压阻式加速度计测量震颤情况。采用高效液相色谱法测定血浆茶碱浓度。
氨茶碱（5.67 - 6.2赫兹）治疗后震颤功率显著高于安慰剂（5.6 - 5.9赫兹）。
我们得出结论，静脉注射氨茶碱在以治疗哮喘所需剂量急性静脉给药时会增强良性特发性震颤。
