Kusumbe Anjali P
Kennedy Institute of Rheumatology, University of Oxford, Roosevelt Drive, Headington, Oxford OX3 7FY, UK; Max-Planck-Institute for Molecular Biomedicine and University of Münster, D-48149 Münster, Germany.
J Bone Oncol. 2016 Jul 21;5(3):112-116. doi: 10.1016/j.jbo.2016.04.003. eCollection 2016 Sep.
The vasculature of the skeletal system regulates osteogenesis and hematopoiesis, in addition to its primary function as a transportation network. Recent studies suggest that the vasculature in bone regulates multiple steps involved in the metastatic cascade. Matrix and growth factor abundant vascular microenvironments in bone not only provide a fertile soil for the metastatic growth but also support the dormancy of Disseminated Tumour Cells (DTCs). Interestingly, vasculature also seems to direct the reactivation of dormant DTCs. Targeting such early steps of bone metastasis by directing therapies against vascular niches can lead to the development of effective therapeutic strategies that delay or even prevent the metastatic relapse. However, this would require a detailed understanding of the regulatory mechanisms that govern the interaction between endothelial cells and DTCs in the early stages of bone metastasis. This review aims to highlight the importance of vascular niches and outline their newly identified roles during bone metastasis.
骨骼系统的脉管系统除了作为运输网络的主要功能外，还调节骨生成和造血。最近的研究表明，骨中的脉管系统调节转移级联反应中的多个步骤。骨中富含基质和生长因子的血管微环境不仅为转移瘤生长提供了肥沃的土壤，还支持播散肿瘤细胞（DTCs）的休眠。有趣的是，脉管系统似乎还能引导休眠DTCs的重新激活。通过针对血管微环境进行治疗来靶向骨转移的这些早期步骤，可能会导致开发出延迟甚至预防转移复发的有效治疗策略。然而，这需要详细了解在骨转移早期阶段控制内皮细胞与DTCs之间相互作用的调节机制。本综述旨在强调血管微环境的重要性，并概述它们在骨转移过程中新发现的作用。
