Morris Emma V, Edwards Claire M
Nuffield Dept. of Surgical Sciences, University of Oxford, Oxford, UK.
Nuffield Dept. of Surgical Sciences, University of Oxford, Oxford, UK; Nuffield Dept. of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.
J Bone Oncol. 2016 Apr 8;5(3):121-123. doi: 10.1016/j.jbo.2016.03.006. eCollection 2016 Sep.
Adipocytes are a significant component of the bone marrow microenvironment. Although bone marrow adipocytes were first identified more than 100 years ago, it is only in recent years that an understanding of their complex physiological role is emerging. Bone marrow adipocytes act as local regulators of skeletal biology and homeostasis, with recent studies suggesting that marrow adipose tissue is metabolically active, and can function as an endocrine organ. As such, bone marrow adipocytes have the potential to interact with tumour cells, influencing both tumour growth and bone disease. This review discusses the current evidence for the role of bone marrow adipocytes in tumour growth within the bone marrow microenvironment and the development of the associated bone disease.
脂肪细胞是骨髓微环境的重要组成部分。尽管骨髓脂肪细胞早在100多年前就被首次发现，但直到近年来，人们才开始了解它们复杂的生理作用。骨髓脂肪细胞作为骨骼生物学和内环境稳态的局部调节因子，最近的研究表明，骨髓脂肪组织具有代谢活性，并且可以作为一个内分泌器官发挥作用。因此，骨髓脂肪细胞有可能与肿瘤细胞相互作用，影响肿瘤生长和骨疾病。这篇综述讨论了目前关于骨髓脂肪细胞在骨髓微环境中肿瘤生长及相关骨疾病发生中作用的证据。
