评价 LDBIO 即时检验用于弓形虫 IgG 和 IgM 的联合检测。
Evaluation of the LDBIO point of care test for the combined detection of toxoplasmic IgG and IgM.
机构信息
Emerging Pathogens Laboratory - Fondation Mérieux, Centre International de Recherche en Infectiologie (CIRI) Inserm U1111, CNRS UMR5308, ENS de Lyon, UCBL1, Lyon, France.
Institut de Parasitologie et de Mycologie Médical, Hôpital de la Croix Rousse, Lyon, France.
出版信息
Clin Chim Acta. 2017 Jan;464:200-201. doi: 10.1016/j.cca.2016.10.023. Epub 2016 Oct 17.
The toxoplasma ICT IgG-IgM rapid diagnostic test for the simultaneous detection of specific toxoplasmic immunoglobulin (Ig) G and IgM was compared with the Architect fully automated chemiluminescence test. Four hundred sera were included, among which 248 scored negative in Architect. The cassettes were easily read with the naked eye. Diagnostic sensitivity and specificity were 97% and 96%, respectively. The test scored 8 false-positive IgG and yielded negative results in 3 sera displaying unspecific IgM in Architect. The LDBIO appears to be a reliable first line test, although the false-positive results for IgG deserve further investigation. Such an easily performed test could be used advantageously for screening for toxoplasmosis in pregnant women.
弓形虫 ICT IgG-IgM 快速诊断试剂盒可同时检测特异性弓形虫免疫球蛋白（Ig）G 和 IgM，与 Architect 全自动化学发光检测法进行比较。共纳入 400 份血清，其中 248 份在 Architect 检测中结果为阴性。用肉眼即可轻松读取检测卡。诊断的敏感性和特异性分别为 97%和 96%。该检测试剂盒出现 8 例 IgG 假阳性，在 Architect 检测中显示非特异性 IgM 的 3 份血清中结果为阴性。LDBIO 似乎是一种可靠的一线检测方法，尽管 IgG 的假阳性结果值得进一步研究。这种易于操作的检测方法可在孕妇中用于筛查弓形虫病。
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