镍暴露与用于评估镍电镀工人氧化应激的生物标志物血浆水平
Nickel exposure and plasma levels of biomarkers for assessing oxidative stress in nickel electroplating workers.
作者信息
Tsao Yu-Chung, Gu Po-Wen, Liu Su-Hsun, Tzeng I-Shiang, Chen Jau-Yuan, Luo Jiin-Chyuan John
机构信息
a Department of Occupational Medicine , Chang Gung Memorial Hospital , Taoyuan , Taiwan.
b Department of Occupational Medicine , Chang Gung Memorial Hospital , Chiayi , Taiwan.
出版信息
Biomarkers. 2017 Jul;22(5):455-460. doi: 10.1080/1354750X.2016.1252964. Epub 2016 Nov 10.
CONTEXT
The mechanism of nickel-induced pathogenesis remains elusive.
OBJECTIVE
To examine effects of nickel exposure on plasma oxidative and anti-oxidative biomarkers.
MATERIALS AND METHODS
Biomarker data were collected from 154 workers with various levels of nickel exposure and from 73 controls. Correlations between nickel exposure and oxidative and anti-oxidative biomarkers were determined using linear regression models.
RESULTS
Workers with a exposure to high nickel levels had significantly lower levels of anti-oxidants (glutathione and catalase) than those with a lower exposure to nickel; however, only glutathione showed an independent association after multivariable adjustment.
DISCUSSION AND CONCLUSION
Exposure to high levels of nickel may reduce serum anti-oxidative capacity.
背景
镍诱导发病的机制仍不清楚。
目的
研究镍暴露对血浆氧化和抗氧化生物标志物的影响。
材料与方法
收集了154名不同镍暴露水平工人和73名对照者的生物标志物数据。使用线性回归模型确定镍暴露与氧化和抗氧化生物标志物之间的相关性。
结果
高镍暴露工人的抗氧化剂（谷胱甘肽和过氧化氢酶）水平显著低于低镍暴露工人；然而，多变量调整后只有谷胱甘肽显示出独立相关性。
讨论与结论
高镍暴露可能会降低血清抗氧化能力。
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