Honda Jennifer R, Hasan Nabeeh A, Davidson Rebecca M, Williams Myra D, Epperson L Elaine, Reynolds Paul R, Smith Terry, Iakhiaeva Elena, Bankowski Matthew J, Wallace Richard J, Chan Edward D, Falkinham Joseph O, Strong Michael
Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado, United States Of America.
Denver Veterans Affairs Medical Center, Denver, Colorado, United States Of America.
PLoS Negl Trop Dis. 2016 Oct 25;10(10):e0005068. doi: 10.1371/journal.pntd.0005068. eCollection 2016 Oct.
Lung disease caused by nontuberculous mycobacteria (NTM) is an emerging infectious disease of global significance. Epidemiologic studies have shown the Hawaiian Islands have the highest prevalence of NTM lung infections in the United States. However, potential environmental reservoirs and species diversity have not been characterized. In this cross-sectional study, we describe molecular and phylogenetic comparisons of NTM isolated from 172 household plumbing biofilms and soil samples from 62 non-patient households and 15 respiratory specimens. Although non-uniform geographic sampling and availability of patient information were limitations, Mycobacterium chimaera was found to be the dominant species in both environmental and respiratory specimens. In contrast to previous studies from the continental U.S., no Mycobacterium avium was identified. Mycobacterium intracellulare was found only in respiratory specimens and a soil sample. We conclude that Hawai'i's household water sources contain a unique composition of Mycobacterium avium complex (MAC), increasing our appreciation of NTM organisms of pulmonary importance in tropical environments.
非结核分枝杆菌（NTM）引起的肺部疾病是一种具有全球意义的新兴传染病。流行病学研究表明，夏威夷群岛是美国NTM肺部感染患病率最高的地区。然而，潜在的环境储存库和物种多样性尚未得到描述。在这项横断面研究中，我们描述了从62户非患者家庭的172个家庭管道生物膜和土壤样本以及15份呼吸道标本中分离出的NTM的分子和系统发育比较。尽管地理采样不均匀和患者信息的可获得性是局限性，但发现chimaera分枝杆菌是环境标本和呼吸道标本中的优势菌种。与美国大陆以前的研究不同，未鉴定出鸟分枝杆菌。细胞内分枝杆菌仅在呼吸道标本和一份土壤样本中发现。我们得出结论，夏威夷的家庭水源含有独特的鸟分枝杆菌复合群（MAC）组成，这增加了我们对热带环境中具有肺部重要性的NTM生物的认识。
