基于原位还原Ni/NiO-石墨烯纳米复合材料的非酶葡萄糖传感器

Nonenzymatic Glucose Sensor Based on In Situ Reduction of Ni/NiO-Graphene Nanocomposite.

作者信息

Zhang Xiaohui, Zhang Zheng, Liao Qingliang, Liu Shuo, Kang Zhuo, Zhang Yue

机构信息

State Key Laboratory for Advanced Metals and Materials, School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing 100083, China.

CRRC Institute, Beijing 100070, China.

出版信息

Sensors (Basel). 2016 Oct 26;16(11):1791. doi: 10.3390/s16111791.

Ni/NiO nanoflower modified reduced graphene oxide (rGO) nanocomposite (Ni/NiO-rGO) was introduced to screen printed electrode (SPE) for the construction of a nonenzymatic electrochemical glucose biosensor. The Ni/NiO-rGO nanocomposite was synthesized by an in situ reduction process. Graphene oxide (GO) hybrid Nafion sheets first chemical adsorbed Ni ions and assembled on the SPE. Subsequently, GO and Ni ions were reduced by hydrazine hydrate. The electrochemical properties of such a Ni/NiO-rGO modified SPE were carefully investigated. It showed a high activity for electrocatalytic oxidation of glucose in alkaline medium. The proposed nonenzymatic sensor can be utilized for quantification of glucose with a wide linear range from 29.9 μM to 6.44 mM (R = 0.9937) with a low detection limit of 1.8 μM (S/N = 3) and a high sensitivity of 1997 μA/mM∙cm. It also exhibited good reproducibility as well as high selectivity.

将镍/氧化镍纳米花修饰的还原氧化石墨烯（rGO）纳米复合材料（Ni/NiO-rGO）引入丝网印刷电极（SPE），用于构建非酶电化学葡萄糖生物传感器。通过原位还原法合成了Ni/NiO-rGO纳米复合材料。氧化石墨烯（GO）与Nafion片材杂化，首先化学吸附镍离子并组装在SPE上。随后，用肼水合物将GO和镍离子还原。对这种Ni/NiO-rGO修饰的SPE的电化学性质进行了仔细研究。它在碱性介质中对葡萄糖的电催化氧化表现出高活性。所提出的非酶传感器可用于定量葡萄糖，线性范围宽，从29.9 μM到6.44 mM（R = 0.9937），检测限低至1.8 μM（S/N = 3），灵敏度高，为1997 μA/mM∙cm。它还表现出良好的重现性和高选择性。