将蔓越莓添加到基于质子泵抑制剂的三联疗法中以进行根除治疗。
Addition of cranberry to proton pump inhibitor-based triple therapy for eradication.
作者信息
Seyyedmajidi Mohammadreza, Ahmadi Anahita, Hajiebrahimi Shahin, Seyedmajidi Seyedali, Rajabikashani Majid, Firoozabadi Mona, Vafaeimanesh Jamshid
机构信息
Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Golestan Province, Iran.
Qom Gastroenterology and Hepatology Research Center, Qom University of Medical Sciences, Qom, Iran; Gastrointestinal and Liver Diseases Research Center, Iran University of Medical Sciences, Tehran, Iran.
出版信息
J Res Pharm Pract. 2016 Oct-Dec;5(4):248-251. doi: 10.4103/2279-042X.192462.
OBJECTIVE
Proton pump inhibitor-based triple therapy with two antibiotics for eradication is widely accepted, but this combination fails in a considerable number of cases. Some studies have shown that cranberry inhibits the adhesion of a wide range of microbial pathogens, including . The aim of this study was to assess the effect of cranberry on eradication with a standard therapy including lansoprazole, clarithromycin, and amoxicillin (LCA) in patients with peptic ulcer disease (PUD).
METHODS
In this study, -positive patients with PUD were randomized into two groups: Group A: A 14-day LCA triple therapy with 30 mg lansoprazole bid, 1000 mg amoxicillin bid, and 500 mg clarithromycin bid; Group B: A 14-day 500 mg cranberry capsules bid plus LCA triple therapy. A C-urea breath test was performed for eradication assessment 6 weeks after the completion of the treatment.
FINDINGS
Two hundred patients (53.5% males, between 23 and 77 years, mean age ± standard deviation: 50.29 ± 17.79 years) continued treatment protocols and underwent C-urea breath testing. eradication was achieved in 74% in Group A (LCA without cranberry) and 89% in Group B (LCA with cranberry) ( = 0.042).
CONCLUSION
The addition of cranberry to LCA triple therapy for has a higher rate of eradication than the standard regimen alone (up to 89% and significant).
目的
基于质子泵抑制剂的三联疗法联合两种抗生素用于根除幽门螺杆菌已被广泛接受，但这种联合疗法在相当多的病例中失败。一些研究表明，蔓越莓能抑制多种微生物病原体的黏附，包括幽门螺杆菌。本研究的目的是评估蔓越莓对消化性溃疡病（PUD）患者采用包括兰索拉唑、克拉霉素和阿莫西林（LCA）的标准疗法根除幽门螺杆菌的效果。
方法
在本研究中，幽门螺杆菌阳性的PUD患者被随机分为两组：A组：采用14天的LCA三联疗法，即兰索拉唑30mg，每日两次，阿莫西林1000mg，每日两次，克拉霉素500mg，每日两次；B组：采用14天的500mg蔓越莓胶囊每日两次加LCA三联疗法。治疗结束6周后进行碳-尿素呼气试验以评估根除情况。
结果
200名患者（男性占53.5%，年龄在23至77岁之间，平均年龄±标准差：50.29±17.79岁）继续治疗方案并接受碳-尿素呼气试验。A组（不含蔓越莓的LCA疗法）的幽门螺杆菌根除率为74%，B组（含蔓越莓的LCA疗法）为89%（P = 0.042）。
结论
在LCA三联疗法中添加蔓越莓用于根除幽门螺杆菌的根除率高于单独使用标准方案（高达89%且具有显著性）。
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