Tsubota H, Lord C I, Watkins D I, Morimoto C, Letvin N L
Harvard Medical School, New England Regional Primate Research Center, Southborough, Massachusetts 01772.
J Exp Med. 1989 Apr 1;169(4):1421-34. doi: 10.1084/jem.169.4.1421.
CD8+ (suppressor/cytotoxic) lymphocytes block replication of HIV-1 or the simian immunodeficiency virus of macaques (SIVmac) in PBL of infected individuals. We now show that these CD8+ lymphocytes undergo clonal expansion in vivo after AIDS virus infection of the individual, suggesting they may be antigen-specific T cells. These CD8+ cells block replication of virus in autologous but not MHC class I-mismatched PBL. The inhibitory lymphocytes express the integrin family molecule 4B4 and the CTL-associated S6F1 epitope of LFA-1. Finally, physical contact is required for the CD8+ lymphocyte-mediated inhibition of AIDS virus replication, since this inhibitory function is blocked by anti-LFA-1 and anti-CD8 mAbs. These studies suggest that the cell that inhibits AIDS virus replication in PBL of infected individuals is a CTL.
CD8 +（抑制性/细胞毒性）淋巴细胞可阻断HIV - 1或猕猴猿猴免疫缺陷病毒（SIVmac）在受感染个体外周血淋巴细胞（PBL）中的复制。我们现在表明，在个体感染艾滋病病毒后，这些CD8 +淋巴细胞在体内会发生克隆扩增，这表明它们可能是抗原特异性T细胞。这些CD8 +细胞可阻断自体而非MHC I类不匹配的PBL中病毒的复制。抑制性淋巴细胞表达整合素家族分子4B4和LFA - 1的CTL相关S6F1表位。最后，CD8 +淋巴细胞介导的艾滋病病毒复制抑制需要细胞间的物理接触，因为这种抑制功能可被抗LFA - 1和抗CD8单克隆抗体阻断。这些研究表明，在受感染个体的PBL中抑制艾滋病病毒复制的细胞是一种细胞毒性T淋巴细胞（CTL）。
