生物学的最新进展：RNA干扰、药物发现与肠道微生物群
Recent advances in biology: RNA interference, drug discovery, and gut microbiome.
作者信息
Morgado Pedro, Manna Dipak, Singh Upinder
机构信息
Division of Infectious Diseases, Department of Internal Medicine, Stanford University School of Medicine, Stanford, California, USA.
Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, USA.
出版信息
F1000Res. 2016 Oct 26;5:2578. doi: 10.12688/f1000research.9241.1. eCollection 2016.
Abstract
In recent years, substantial progress has been made in understanding the molecular and cell biology of the human parasite , an important pathogen with significant global impact. This review outlines some recent advances in the field in the last five years, focusing on areas that have not recently been discussed in detail: (i) molecular mechanisms regulating parasite gene expression, (ii) new efforts at drug discovery using high-throughput drug screens, and (iii) the effect of gut microbiota on amoebiasis.
摘要
近年来，在了解这种对全球具有重大影响的重要病原体——人体寄生虫的分子和细胞生物学方面取得了重大进展。本综述概述了过去五年该领域的一些最新进展，重点关注近期未详细讨论的领域：（i）调节寄生虫基因表达的分子机制，（ii）利用高通量药物筛选进行药物发现的新努力，以及（iii）肠道微生物群对阿米巴病的影响。
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