Moloney W C
Cancer. 1978 Aug;42(2 Suppl):865-73. doi: 10.1002/1097-0142(197808)42:2+<865::aid-cncr2820420708>3.0.co;2-p.
Chronic myelogenous leukemia (CML) is a relatively rare disease, with a number of features that make it especially suitable for observations on leukemogenesis in man. These include known etiologic agents, often a prolonged preclinical and active stage, cells with identifiable morphological and histochemical characteristics and the presence of the unique Ph' chromosome. The transition of CML to blast crisis is a catastrophic event; however, recent clinical and biochemical studies have raised important questions as to the nature and origin of blast cells in this disease. During the past 10 years, we have followed 113 cases olf CML throughout their course and results of observations on the clinical, hematological and other apsects of the disease are presented in this communication.
慢性粒细胞白血病（CML）是一种相对罕见的疾病，具有许多使其特别适合于人类白血病发生观察的特征。这些特征包括已知的病因、通常较长的临床前期和活动期、具有可识别的形态学和组织化学特征的细胞以及独特的费城染色体（Ph'染色体）的存在。CML向急变期的转变是一个灾难性事件；然而，最近的临床和生化研究对该疾病中原始细胞的性质和起源提出了重要问题。在过去10年中，我们对113例CML患者进行了全程跟踪，本文介绍了对该疾病临床、血液学及其他方面的观察结果。
