Mulero J, Alvarez-Mon M, de Villa L F, Rodríguez M, Noguera E, Martín-Santos J M, Gutiérrez C
Department of Rheumatology, Clínica Puerta de Hierro, Madrid, Spain.
Ann Rheum Dis. 1989 May;48(5):400-5. doi: 10.1136/ard.48.5.400.
The presence of factors implicated in B cell proliferation and differentiation was studied in synovial fluid (SF) from patients with rheumatoid arthritis (RA) and from patients with ankylosing spondylitis (AS) and traumatic joint injury. Culture with Staphylococcus aureus Cowan I B cell blasts showed strong B cell growth factor (BCGF) activity in the SF from patients with RA. This BCGF activity was significantly greater than that found in SF from patients with traumatic joint injury and similar to that of patients with AS. The presence of B cell differentiation factor (BCDF) for IgM(mu) in the SF from patients with RA was also demonstrated and was significantly greater than that found in SF from patients with AS and traumatic joint injury. Moreover, a significantly increased BCDF for IgG(gamma) was also found in the SF from patients with RA compared with that observed in those patients with traumatic joint injury, which, however, was similar to that of patients with AS.
对类风湿性关节炎（RA）患者、强直性脊柱炎（AS）患者以及创伤性关节损伤患者的滑液（SF）中与B细胞增殖和分化相关的因子进行了研究。用金黄色葡萄球菌考恩I型培养B细胞母细胞，结果显示RA患者的滑液具有较强的B细胞生长因子（BCGF）活性。这种BCGF活性显著高于创伤性关节损伤患者的滑液，与AS患者的滑液相似。在RA患者的滑液中也证实了存在针对IgM（μ）的B细胞分化因子（BCDF），且显著高于AS患者和创伤性关节损伤患者的滑液。此外，与创伤性关节损伤患者相比，RA患者的滑液中针对IgG（γ）的BCDF也显著增加，不过与AS患者的相似。
