细胞因子与风湿性疾病的慢性炎症。I. 滑液中白细胞介素-1的存在。
Cytokines and the chronic inflammation of rheumatic disease. I. The presence of interleukin-1 in synovial fluids.
作者信息
Nouri A M, Panayi G S, Goodman S M
出版信息
Clin Exp Immunol. 1984 Feb;55(2):295-302.
Abstract
Synovial fluids from patients with rheumatoid arthritis (13 cases), ankylosing spondylitis (six), psoriatic arthritis (two), osteoarthritis (three) and rubella arthritis (four) contain interleukin-1 (Il-1) activity as measured in the CH3/He mouse thymocyte assay. That this activity is Il-1 was shown by: (i) the time course of thymocyte stimulation; (ii) failure of PHA blast cells to absorb out the activity; (iii) molecular weight of 15,000-20,000 daltons, and (iv) ability to stimulate prostaglandin E2 production from synovial cells. These results indicate that IL-1 is an important mediator in the inflammatory pathway of different types of joint disease.
摘要
在CH3/He小鼠胸腺细胞试验中检测发现，类风湿性关节炎患者（13例）、强直性脊柱炎患者（6例）、银屑病关节炎患者（2例）、骨关节炎患者（3例）和风疹性关节炎患者（4例）的滑液含有白细胞介素-1（IL-1）活性。该活性为IL-1可通过以下几点证明：（i）胸腺细胞刺激的时间进程；（ii）PHA母细胞无法消除该活性；（iii）分子量为15,000 - 20,000道尔顿；（iv）刺激滑膜细胞产生前列腺素E2的能力。这些结果表明，IL-1是不同类型关节疾病炎症途径中的重要介质。
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