Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, USA.
Nat Immunol. 2019 Jul;20(7):770-774. doi: 10.1038/s41590-019-0416-z.
Over 30 key leaders in the field participated in a 1-day workshop entitled ‘Recent Advances and Opportunities in the Development and Use of Humanized Immune System Mouse Models’ to discuss the benefits and limitations of using human fetal tissue versus non-fetal tissue sources to generate mice with a humanized immune system. This Comment summarizes the workshop discussions, including highlights of some of the key advances made through the use of humanized mice in improving the understanding of immune system function and developing novel therapeutics for the treatment of infectious, immunological and allergic diseases, as well as current challenges in the production, characterization and utilization of these animal models.
超过 30 位该领域的主要专家参加了为期一天的研讨会，主题为“人源化免疫系统小鼠模型的开发和应用的最新进展和机遇”，以讨论使用人胎组织与非胎组织来源来生成具有人源化免疫系统的小鼠的优势和局限性。本述评总结了研讨会的讨论内容，包括通过使用人源化小鼠在提高对免疫系统功能的理解和开发用于治疗传染病、免疫和过敏疾病的新型疗法方面取得的一些关键进展的要点，以及在这些动物模型的生产、鉴定和应用方面当前面临的挑战。
