用于研究人类病毒感染和发病机制的人源化小鼠模型。
Humanized Mouse Models for the Study of Infection and Pathogenesis of Human Viruses.
机构信息
Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore 138673, Singapore.
Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore.
出版信息
Viruses. 2018 Nov 17;10(11):643. doi: 10.3390/v10110643.
Abstract
The evolution of infectious pathogens in humans proved to be a global health problem. Technological advancements over the last 50 years have allowed better means of identifying novel therapeutics to either prevent or combat these infectious diseases. The development of humanized mouse models offers a preclinical in vivo platform for further characterization of human viral infections and human immune responses triggered by these virus particles. Multiple strains of immunocompromised mice reconstituted with a human immune system and/or human hepatocytes are susceptible to infectious pathogens as evidenced by establishment of full viral life cycles in hope of investigating viral⁻host interactions observed in patients and discovering potential immunotherapies. This review highlights recent progress in utilizing humanized mice to decipher human specific immune responses against viral tropism.
摘要
人类感染性病原体的进化被证明是一个全球性的健康问题。过去 50 年来的技术进步为发现新的治疗方法提供了更好的手段，以预防或对抗这些传染病。人源化小鼠模型的发展为进一步研究人类病毒感染和这些病毒颗粒引发的人类免疫反应提供了一个临床前体内平台。多种免疫功能低下的小鼠经过重建，具有人类免疫系统和/或人类肝细胞，容易受到感染性病原体的感染，这一点从完整的病毒生命周期的建立中可以得到证明，其目的是研究患者中观察到的病毒-宿主相互作用，并发现潜在的免疫疗法。本文综述了利用人源化小鼠来解析人类针对病毒嗜性的特异性免疫反应的最新进展。
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