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与常见急性淋巴细胞白血病(ALL)细胞相关的一种抗原结构的部分分子特征

Partial molecular characterization of an antigenic structure associated to cells of common acute lymphocytic leukaemia (ALL).

作者信息

Kabisch H, Arndt R, Thiele H G, Winkler K, Landbeck G

出版信息

Clin Exp Immunol. 1978 Jun;32(3):399-404.

PMID:278685
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1541318/
Abstract

A heteroantiserum against common human acute lymphocytic leukaemia (ALL) cells was raised in rabbits. This antiserum was rendered specific for common ALL cells by extensive absorption with different human tissue. A specific antigen associated to common ALL cells was solubilized by sodium deoxycholate from ALL plasma membranes and identified by indirect immunofluorescence. By analytical chromatography, two antigenically active peaks were found. The apparent molecular weights were calculated to be 55,000 and 110,000.

摘要

用兔制备了一种针对人类常见急性淋巴细胞白血病(ALL)细胞的异种抗血清。通过用不同人体组织进行广泛吸收,使该抗血清对常见ALL细胞具有特异性。用脱氧胆酸钠从ALL细胞膜中溶解出与常见ALL细胞相关的一种特异性抗原,并通过间接免疫荧光进行鉴定。通过分析色谱法,发现了两个具有抗原活性的峰。计算出的表观分子量分别为55,000和110,000。

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Partial molecular characterization of an antigenic structure associated to cells of common acute lymphocytic leukaemia (ALL).与常见急性淋巴细胞白血病(ALL)细胞相关的一种抗原结构的部分分子特征
Clin Exp Immunol. 1978 Jun;32(3):399-404.
2
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引用本文的文献

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Detection of the common acute lymphoblastic leukemia antigen in the serum of leukemia patients.白血病患者血清中常见急性淋巴细胞白血病抗原的检测
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New antigenic determinant common to human thymus leukaemia-associated antigens and common acute lymphoblastic leukaemia antigen.人类胸腺白血病相关抗原与常见急性淋巴细胞白血病抗原所共有的新抗原决定簇。
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本文引用的文献

1
Preliminary characterization of Thy-1.1 and Ag-B antigens from rat tissues solubilized in detergents.对用去污剂溶解的大鼠组织中Thy-1.1和Ag-B抗原的初步表征。
Biochem J. 1974 Oct;143(1):51-61. doi: 10.1042/bj1430051.
2
Antisera to acute lymphoblastic leukemia cells.抗急性淋巴细胞白血病细胞血清。
Clin Immunol Immunopathol. 1975 May;4(1):67-84. doi: 10.1016/0090-1229(75)90041-0.
3
Distribution of Ia-like molecules on the surface of normal and leukemic human cells.Ia样分子在正常和白血病人类细胞表面的分布。
Proc Natl Acad Sci U S A. 1976 Apr;73(4):1288-92. doi: 10.1073/pnas.73.4.1288.
4
Human B-lymphocyte antigens expressed by lymphocytic and myelocytic leukemia cells. I. Detection by rabbit antisera.淋巴细胞性和髓细胞性白血病细胞表达的人类B淋巴细胞抗原。I. 用兔抗血清检测
J Exp Med. 1976 Jul 1;144(1):167-78. doi: 10.1084/jem.144.1.167.
5
Classification of leukemic cells with T- and O-ALL-specific antisera.使用T-ALL和O-ALL特异性抗血清对白血病细胞进行分类。
Haematol Blood Transfus. 1977;20:87-96. doi: 10.1007/978-3-642-66639-1_9.
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[Cytological classification and nomenclature of leukaemias in childhood. Present situation of the cytomorphological and cytochemical differentiation (author's transl)].
Klin Padiatr. 1977 Jan;189(8):14-21.
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Detection and molecular characterization of the thymus-brain antigen in human brain.人类大脑中胸腺-脑抗原的检测及分子特征分析。
Immunology. 1977 Jul;33(1):101-7.
8
Solubilization and molecular characterization of membrane-bound antigens shared by thymocytes and brain.胸腺细胞和脑共有的膜结合抗原的溶解及分子特征分析
Eur J Immunol. 1976 May;6(5):333-40. doi: 10.1002/eji.1830060506.
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Detection of monocyte specific antigen on human acute leukaemia cells.人急性白血病细胞上单核细胞特异性抗原的检测
Br J Haematol. 1976 Jan;32(1):13-19. doi: 10.1111/j.1365-2141.1976.tb01870.x.
10
A surface antigen marker for human monocytes.一种人类单核细胞的表面抗原标志物。
Scand J Immunol. 1975 Sep;4(5-6):555-62. doi: 10.1111/j.1365-3083.1975.tb02661.x.