Casanova Marcela A, Medeiros Fernanda, Trindade Michelle, Cohen Célia, Oigman Wille, Neves Mario Fritsch
Department of Clinical Medicine, State University of Rio de Janeiro, Rio de Janeiro, Brazil.
Department of Applied Nutrition, Federal University of the State of Rio de Janeiro, Rio de Janeiro, Brazil.
J Am Soc Hypertens. 2017 Jan;11(1):10-19. doi: 10.1016/j.jash.2016.10.004. Epub 2016 Oct 26.
Association between hypertriglyceridemia and cardiovascular (CV) disease is still controversial. The purpose of this study was to compare omega-3 and ciprofibrate effects on the vascular structure and function in low and high CV risk hypertensive patients with hypertriglyceridemia. Twenty-nine adults with triglycerides 150-499 mg/dL were divided into low (<7.5%) and high (≥7.5%) CV risk, randomized to receive omega-3 fatty acids 1800 mg/d or ciprofibrate 100 mg/d for 12 weeks. Treatment was switched after 8-week washout. Clinical evaluation and vascular tests were assessed at baseline and after intervention. Peripheral (131 ± 3 to 125 ± 3 mm Hg, P < .05) and aortic (124 ± 3 to 118 ± 2 mg/dL, P < .05) systolic blood pressure were decreased by ciprofibrate in low-risk patients. In high-risk patients, pulse wave velocity was reduced (10.4 ± 0.4 to 9.4 ± 0.3 m/s, P < .05) and flow-mediated dilation was increased (11.1 ± 1.6 to 13.5 ± 1.2%, P < .05) by omega-3. In conclusion, omega-3 improved arterial stiffness and endothelial function, pointing out the beneficial effect of this therapy on vascular aging, in high-risk patients.
高甘油三酯血症与心血管疾病之间的关联仍存在争议。本研究的目的是比较ω-3脂肪酸和环丙贝特对高甘油三酯血症的低心血管风险和高心血管风险高血压患者血管结构和功能的影响。29名甘油三酯水平在150 - 499mg/dL的成年人被分为低（<7.5%）心血管风险组和高（≥7.5%）心血管风险组，随机接受12周的每日1800mgω-3脂肪酸或每日100mg环丙贝特治疗。8周洗脱期后更换治疗方案。在基线和干预后进行临床评估和血管测试。环丙贝特使低风险患者的外周收缩压（从131±3降至125±3mmHg，P<0.05）和主动脉收缩压（从124±3降至118±2mg/dL，P<0.05）降低。在高风险患者中，ω-3脂肪酸使脉搏波速度降低（从10.4±0.4降至9.4±0.3m/s，P<0.05），并使血流介导的血管舒张增加（从11.1±1.6%增至13.5±1.2%，P<0.05）。总之，ω-3脂肪酸改善了高风险患者动脉僵硬度和内皮功能，表明该疗法对血管老化具有有益作用。
