Beaudart Charlotte, Biver Emmanuel, Reginster Jean-Yves, Rizzoli René, Rolland Yves, Bautmans Ivan, Petermans Jean, Gillain Sophie, Buckinx Fanny, Dardenne Nadia, Bruyère Olivier
Department of Public Health, Epidemiology, and Health Economics, University of Liège, Quartier Hôpital, Liège, Belgium.
Division of Bone Diseases, Geneva University Hospitals and Faculty of Medicine, Geneva 14, Switzerland.
J Cachexia Sarcopenia Muscle. 2017 Apr;8(2):238-244. doi: 10.1002/jcsm.12149. Epub 2016 Oct 22.
A specific self-administrated health-related quality of life questionnaire for sarcopenia, the Sarcopenia and Quality Of Life (SarQoL®), has been recently developed. This questionnaire is composed of 55 items translated into 22 questions and organized into seven domains of quality of life. The objective of the present work is to evaluate the psychometric properties (discriminative power, validity, reliability, floor and ceiling effects) of the SarQoL® questionnaire.
Sarcopenic subjects were recruited in an outpatient clinic in Liège, Belgium and were diagnosed according to the algorithm developed by the European Working Group on Sarcopenia in Older People. We compared the score of the SarQoL® between sarcopenic and non-sarcopenic subjects using a logistic regression after adjustment for potential confounding variables. Internal consistency reliability was determined using Cronbach's alpha coefficient; construct validity was assessed using convergent and divergent validities. Test-retest reliability was verified after a two-week interval using the intra-class correlation coefficient (ICC). At last, floor and ceiling effects were also tested.
A total of 296 subjects with a median age of 73.3 (68.9-78.6) years were recruited for this study. Among them, 43 were diagnosed sarcopenic. After adjustment for potential confounding factors, the total score and the scores of the different dimensions of the SarQoL® questionnaire were significantly lower for sarcopenic than for non-sarcopenic subjects (54.7 (45.9-66.3) for sarcopenic vs. 67.8 (57.3 - 79.0) for non sarcopenic, OR 0.93 (95%CI 0.90-0.96)). Regarding internal consistency, the Cronbach's alpha coefficient was 0.87. The SarQoL® questionnaire data showed good correlation with some domains of the Short-Form 36 (SF-36) and the EuroQoL 5-dimension (EQ-5D) questionnaires and with the mobility test. An excellent agreement between the test and the retest was found with an ICC of 0.91 (95% CI 0.82-0.95). At last, neither floor nor ceiling effects were detected.
The SarQoL® questionnaire is valid, consistent, and reliable and can therefore be recommended for clinical and research purposes. However, its sensitivity to change needs to be assessed in future longitudinal studies.
最近开发了一种针对肌肉减少症的特定自我管理的健康相关生活质量问卷，即肌肉减少症与生活质量问卷（SarQoL®）。该问卷由55个项目组成，转化为22个问题，并分为七个生活质量领域。本研究的目的是评估SarQoL®问卷的心理测量特性（区分能力、效度、信度、地板效应和天花板效应）。
在比利时列日的一家门诊诊所招募肌肉减少症患者，并根据老年人肌肉减少症欧洲工作组制定的算法进行诊断。在对潜在混杂变量进行调整后，我们使用逻辑回归比较了肌肉减少症患者和非肌肉减少症患者的SarQoL®得分。使用Cronbach's alpha系数确定内部一致性信度；使用收敛效度和发散效度评估结构效度。在两周间隔后使用组内相关系数（ICC）验证重测信度。最后，还测试了地板效应和天花板效应。
本研究共招募了296名受试者，中位年龄为73.3（68.9 - 78.6）岁。其中，43人被诊断为肌肉减少症。在对潜在混杂因素进行调整后，肌肉减少症患者的SarQoL®问卷总分及不同维度得分显著低于非肌肉减少症患者（肌肉减少症患者为54.7（45.9 - 66.3），非肌肉减少症患者为67.8（57.3 - 79.0），比值比为0.93（95%置信区间0.90 - 0.96））。关于内部一致性，Cronbach's alpha系数为0.87。SarQoL®问卷数据与简短健康调查问卷36项（SF - 36）和欧洲五维健康量表（EQ - 5D）问卷的某些领域以及与运动测试显示出良好的相关性。重测结果显示出极好的一致性，ICC为0.91（95%置信区间0.82 - 0.95）。最后，未检测到地板效应和天花板效应。
SarQoL®问卷有效、一致且可靠，因此可推荐用于临床和研究目的。然而，其对变化的敏感性需要在未来的纵向研究中进行评估。
