Li Ying, Huang Ke, Ji Pei Li, Song Lei, Liu Hong Tu
National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
Department of Obstetrics and Gynaecology, Chinese PLA General Hospital, Beijing 100853, China.
Biomed Environ Sci. 2016 Oct;29(10):734-741. doi: 10.3967/bes2016.098.
This study was designed to determine the prevalence of oncogenic human papillomavirus (HPV) in cervical infections in Beijing, China, and to investigate the odds ratio (OR) of HPV single and multiple infections in abnormal cytology.
A total of 19,018 specimens from outpatients in the department of obstetric and gynecology were collected. They were detected using high-risk HPV genotyping real-time polymerase chain reaction (PCR) kit and analyzed by ThinPrep cytology test for cervical pathological diagnosis. HPV prevalence, age-specific prevalence, and OR of each type of HPV in abnormal cytology were analyzed.
Overall, 19.1% (3,623/19,018) of the individuals were positive for HPV infection, 14.9% (2,833/19,018) were positive for a single HPV type, and 4.2% (790/19,018) were positive for multiple types. Among the 3,623 HPV-positive individuals, the most predominant HPV types were HPV52 (4.4%, 834/19,018), HPV16 (3.7%, 710/19,018), and HPV58 (3.4%, 644/19,018). The OR of multiple infections and single infection differed significantly among disease severities. The OR of dual infection was higher than that of each of the two single infection types, respectively.
HPV prevalence in the outpatients was 19.1%, and the most predominant HPV types in the study were HPV52, HPV16, and HPV58. Women with multiple infectionswere more likely to have abnormal cytology.
本研究旨在确定中国北京地区宫颈感染中致癌性人乳头瘤病毒（HPV）的流行率，并调查异常细胞学中HPV单一感染和多重感染的比值比（OR）。
共收集了19018例妇产科门诊患者的样本。使用高危型HPV基因分型实时聚合酶链反应（PCR）试剂盒进行检测，并通过ThinPrep细胞学检测进行宫颈病理诊断分析。分析了HPV流行率、年龄特异性流行率以及异常细胞学中各型HPV的OR。
总体而言，19.1%（3623/19018）的个体HPV感染呈阳性，14.9%（2833/19018）为单一HPV型别阳性，4.2%（790/19018）为多重感染阳性。在3623例HPV阳性个体中，最主要的HPV型别为HPV52（4.4%，834/19018）、HPV16（3.7%，710/19018）和HPV58（3.4%，644/19018）。多重感染和单一感染的OR在疾病严重程度之间存在显著差异。双重感染的OR分别高于两种单一感染类型中的每一种。
门诊患者中HPV流行率为19.1%，研究中最主要的HPV型别为HPV52、HPV16和HPV58。多重感染的女性更易出现异常细胞学表现。
