College of Computer Science, Sichuan University, Chengdu, 610065, China.
Department of Obstetrics and Gynaecology PLA General Hospital, Beijing, 100853, China.
BMC Bioinformatics. 2020 May 5;21(Suppl 7):152. doi: 10.1186/s12859-020-3454-5.
Cervical cancer is the fourth most common tumor in women worldwide, mostly resulting from high-risk human papillomavirus (HR-HPV) with persistent infection.
The present discoveries are comprised of the following: (i) A total of 16.64% of the individuals were positive for HR-HPV infection, with 13.04% having a single HR-HPV type and 3.60% having multiple HR-HPV types. (ii) Cluster analysis showed that the infection rate trends of HPV31 and HPV33 in all infections as well as HPV33 and HPV35 in single infections in precancerous stages were very similar. (iii) The single/multiple infection proportions of HR-HPV demonstrated a trend that the multiple infections rates of HR-HPV increased as the disease developed.
The HR-HPV prevalence in outpatients was 16.64%, and the predominant HR-HPV types in the study were HPV52, HPV58 and HPV16. HR-HPV subtypes with common biological properties had similar infection rate trends in precancerous stages. Especially, as the disease development of precancer evolved, defense against HPV infection broke, meanwhile, the potential of more HPV infection increased, which resulted in increase of multiple infections of HPV.
宫颈癌是全球女性中第四常见的肿瘤，主要由高危型人乳头瘤病毒（HR-HPV）持续感染引起。
本研究的发现包括以下内容：（i）共有 16.64%的个体 HR-HPV 感染呈阳性，其中 13.04%为单一 HR-HPV 型，3.60%为多重 HR-HPV 型。（ii）聚类分析显示，所有感染中 HPV31 和 HPV33 的感染率趋势以及癌前病变阶段单一感染中 HPV33 和 HPV35 的感染率趋势非常相似。（iii）HR-HPV 的单一/多重感染比例表明，随着疾病的发展，HR-HPV 的多重感染率呈上升趋势。
本研究中门诊患者 HR-HPV 的感染率为 16.64%，主要的 HR-HPV 亚型为 HPV52、HPV58 和 HPV16。具有共同生物学特性的 HR-HPV 亚型在癌前阶段具有相似的感染率趋势。特别是随着癌前病变的发展，对 HPV 感染的防御被打破，同时，更多 HPV 感染的可能性增加，导致 HPV 多重感染的增加。
