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乳腺癌术后光子放射治疗中应用黄铜网塞的剂量学评估。

Dosimetric assessment of brass mesh bolus for postmastectomy photon radiotherapy.

机构信息

University of California San Diego.

出版信息

J Appl Clin Med Phys. 2016 Jul 25;17(6):86-96. doi: 10.1120/jacmp.v17i6.6221.

Abstract

Brass mesh bolus has been shown to be an acceptable substitute for tissue-equivalent bolus to increase superficial dose for chest wall tangent photon radiotherapy. This work investigated the increase in surface dose, the change in the dose at depth, and the safety implications of higher energy photon beams when using brass mesh bolus for postmastectomy chest wall radiotherapy. A photon tangent plan was delivered to a thorax phantom, and the superficial dose ranged from 40%-72% of prescription dose with no bolus. The surface dose increased to 75%-110% of prescription dose with brass mesh bolus and 85%-109% of prescription dose with tissue-equivalent bolus. It was also found that the dose at depth when using brass mesh bolus is comparable to that measured with no bolus for en face and oblique incidence. Monte Carlo calculations were used to assess the photoneutron production from brass mesh bolus used with 15 MV and 24 MV photon beams. The effective dose from photoneutrons was approximated and found to be relatively small, yet not negligible. Activation products generated by these photoneutrons, the surface dose rate due to the activation products, and the half-life of the activation products were also considered in this work. The authors conclude that brass mesh bolus is a reasonable alternative to tissue-equivalent bolus, and it may be used with high-energy beam; but one should be aware of the potential increased effective dose to staff and patients due to the activation products produced by photoneutrons.

摘要

黄铜网塞已被证明可作为组织等效物塞的可接受替代品,用于增加胸壁切线光子放射治疗的表面剂量。本研究调查了在乳腺癌根治术后胸壁放射治疗中使用黄铜网塞时,高能光子束增加表面剂量、深度剂量变化和安全性的影响。对胸部体模进行了光子切线计划治疗,在没有塞子的情况下,浅层剂量范围为处方剂量的 40%-72%。使用黄铜网塞时,表面剂量增加至处方剂量的 75%-110%,使用组织等效塞子时,表面剂量增加至处方剂量的 85%-109%。还发现,当使用黄铜网塞时,深度剂量与无塞子时的迎面和斜入射测量值相当。蒙特卡罗计算用于评估 15 MV 和 24 MV 光子束中使用的黄铜网塞产生的光中子。近似估计了光中子产生的有效剂量,发现虽然较小,但并非可以忽略不计。还考虑了这些光中子产生的放射性核素、由于放射性核素产生的表面剂量率以及放射性核素的半衰期。作者得出结论,黄铜网塞是组织等效塞的合理替代品,可与高能束一起使用;但应注意由于光中子产生的放射性核素,工作人员和患者的潜在有效剂量增加。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72b9/5690501/5b5a5ab52add/ACM2-17-086-g001.jpg

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