Day Rachael, Eddleston Michael, Thomas Simon H L, Thompson John P, Vale J Allister
a NPIS (Birmingham Unit) , City Hospital , Birmingham , UK.
b NPIS (Edinburgh Unit) , Royal Infirmary , Edinburgh , UK.
Clin Toxicol (Phila). 2017 Mar;55(3):206-212. doi: 10.1080/15563650.2016.1264588. Epub 2016 Dec 8.
Traditional automatic dishwashing tablets are contained within an external wrapper that requires removal prior to use.
To determine the toxicity of traditional tablets and to compare this with our previously reported experience of soluble film dishwashing tablets.
Telephone enquiries regarding traditional tablets were analysed retrospectively for the period January 2008 to December 2015.
Traditional tablets: There were 503 enquiries relating to 492 patients who had been exposed to a traditional tablet. Most involved children aged 5 years or less (87.4%). The majority (78.6%) of patients did not develop symptoms after exposure; 21.1% developed minor (PSS 1) symptoms while one patient developed moderate features. Exposure occurred predominantly as a result of ingestion (n = 476, 96.7%); the most common feature in symptomatic patients (n = 99, 20.8%) was vomiting (70 [14.7%] cases). Significantly (p < 0.0001) more adults (44.9% of 49 adults; 95% CI = 31.9-58.7) were reported with features than children (18.2% of 434; 95% CI = 14.9-22.1). There were five cases of eye contact which resulted in eye pain in two patients and eye irritation in another. Only one of 11 patients exposed dermally developed features (a rash around the mouth). Comparison with soluble film exposures: The percentage of patients that were reported with clinical symptoms following ingestion of a soluble film dishwashing tablet (31.7% of 473 patients; 95% CI = 27.7-36.0) was significantly greater (p < 0.0001) than that for a traditional tablet (20.9% of 483 patients; 95% CI = 17.5-24.8). Vomiting was the most commonly reported feature and occurred significantly (p < 0.0001) more frequently amongst patients who had ingested a soluble film tablet (25.5%; 95% CI = 21.8-29.6) than a traditional tablet (14.7%; 95% CI = 11.8-18.1).
Exposure to both traditional and soluble film tablets only rarely produced clinically significant symptoms (PSS ≥2). However, ingestion of a soluble film tablet was significantly more likely to result in clinical features than ingestion of a traditional tablet.
传统自动洗碗机片剂包含在外部包装内,使用前需要拆除包装。
确定传统片剂的毒性,并将其与我们之前报道的可溶性薄膜洗碗机片剂的情况进行比较。
回顾性分析2008年1月至2015年12月期间关于传统片剂的电话咨询。
传统片剂:有503次咨询涉及492名接触过传统片剂的患者。大多数患者为5岁及以下儿童(87.4%)。大多数患者(78.6%)接触后未出现症状;21.1%出现轻微(PSS 1)症状,1名患者出现中度症状。接触主要是由于摄入(n = 476,96.7%);有症状患者(n = 99,20.8%)中最常见的症状是呕吐(70例[14.7%])。报告出现症状的成年人(49名成年人中的44.9%;95%CI = 31.9 - 58.7)显著多于儿童(434名儿童中的18.2%;95%CI = 14.9 - 22.1)(p < 0.0001)。有5例眼部接触,其中2例导致眼痛,另1例导致眼部刺激。11名皮肤接触患者中只有1名出现症状(口周皮疹)。与可溶性薄膜接触情况的比较:摄入可溶性薄膜洗碗机片剂后报告有临床症状的患者比例(473名患者中的31.7%;95%CI = 27.7 - 36.0)显著高于传统片剂(483名患者中的20.9%;95%CI = 17.5 - 24.8)(p < 0.0001)。呕吐是最常报告的症状,摄入可溶性薄膜片剂的患者中呕吐发生率(25.5%;95%CI = 21.8 - 29.6)显著高于传统片剂(14.7%;95%CI = 11.8 - 18.1)(p < 0.0001)。
接触传统片剂和可溶性薄膜片剂很少产生具有临床意义的症状(PSS≥2)。然而,摄入可溶性薄膜片剂比摄入传统片剂更有可能导致出现临床症状。