NPIS (Birmingham Unit), City Hospital, Birmingham, UK.
Clin Toxicol (Phila). 2012 Sep;50(8):776-80. doi: 10.3109/15563650.2012.709937. Epub 2012 Jul 27.
To ascertain the reported toxicity of liquid detergent capsules.
Between 1 March 2008 and 30 April 2009 the UK National Poisons Information Service collected prospectively 647 telephone enquiries relating to liquid detergent capsules.
The majority of enquiries (96.1%) concerned children of 5 years of age or less. Exposure to these products occurred mainly as a result of ingestion alone (n = 518; 80.1%), with eye contact alone (n = 61; 9.4%), and skin contact alone (n = 7; 1.1%) being less common; multiple routes of exposure were involved in 61 (9.4%) enquiries. Following ocular exposure, conjunctivitis with or without eye pain (n = 61), eye pain alone (n = 11) and keratitis (n = 4) developed; in one case the keratitis persisted for nine days, though recovery occurred in all cases as far as is known. The most common features reported following ingestion alone were nausea and vomiting (n = 143), followed by coughing (n = 21). Eleven children less than 2 years of age also developed drowsiness. A rash occurred in nine patients where ingestion was considered to be the route of exposure, probably due to topical contact with the capsule. Seven children aged 3 or less were exposed via the dermal route alone and developed rash (n = 4), irritation (n = 2), chemical burn (n = 2), and paresthesia (n = 1).
Ocular exposure may lead to conjunctivitis and keratitis; recovery is to be expected in all cases within 7-10 days. Ingestion may also result in drowsiness. Greater consumer awareness is required to reduce injury from liquid detergent capsules, particularly that involving the eye. Parents have a vital role to play in ensuring that these products are stored safely at all times.
确定液体洗涤剂胶囊的报告毒性。
2008 年 3 月 1 日至 2009 年 4 月 30 日期间,英国国家毒物信息服务处前瞻性收集了 647 例与液体洗涤剂胶囊相关的电话咨询。
大多数咨询(96.1%)涉及 5 岁或以下的儿童。这些产品的暴露主要是由于摄入(n = 518;80.1%),单独眼部接触(n = 61;9.4%)和单独皮肤接触(n = 7;1.1%)较少见;61 例(9.4%)咨询涉及多种途径暴露。眼部暴露后,出现结膜炎伴或不伴眼痛(n = 61)、单纯眼痛(n = 11)和角膜炎(n = 4);在一例中,角膜炎持续了九天,但据所知,所有病例均已恢复。单独摄入后最常见的报告特征是恶心和呕吐(n = 143),其次是咳嗽(n = 21)。11 名年龄小于 2 岁的儿童也出现嗜睡。在考虑摄入为暴露途径的 9 例患者中出现皮疹,可能是由于胶囊的局部接触。7 名年龄为 3 岁或以下的儿童单独经皮肤途径暴露,出现皮疹(n = 4)、刺激(n = 2)、化学烧伤(n = 2)和感觉异常(n = 1)。
眼部暴露可能导致结膜炎和角膜炎;预计所有病例在 7-10 天内均可恢复。摄入也可能导致嗜睡。需要提高消费者的认识,以减少液体洗涤剂胶囊造成的伤害,特别是眼部伤害。家长在确保这些产品始终安全储存方面发挥着至关重要的作用。