Novel antitumor antibiotic phospholine. 2. Structure determination.
作者信息
Ozasa T, Tanaka K, Sasamata M, Kaniwa H, Shimizu M, Matsumoto H, Iwanami M
机构信息
Central Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd., Tokyo, Japan.
出版信息
J Antibiot (Tokyo). 1989 Sep;42(9):1339-43. doi: 10.7164/antibiotics.42.1339.
PMID:2793587
Abstract
Phospholine, an antitumor antibiotic, has the molecular formula of C25H40NO8P and possesses a delta-lactone and a phosphoric acid ester as functional groups. Its structure was determined based on interpretation of fast atom bombardment MS, 1H NMR, 13C NMR, 1H-1H correlation spectroscopy (COSY), 13C-1H COSY, heteronuclear multiple bond correlation spectroscopy, elemental analysis and chemical modifications.
摘要
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