Foster P N, Wyatt J I, Bullimore D W, Losowsky M S
Department of Medicine, St James's University Hospital, Leeds.
J Clin Pathol. 1989 Sep;42(9):919-21. doi: 10.1136/jcp.42.9.919.
To determine whether the "congestive" gastropathy associated with portal hypertension showed distinctive histological features independent of inflammatory gastritis, endoscopic biopsy specimens of gastric mucosa from 23 patients with portal hypertension and 25 patients with non-ulcer dyspepsia were examined. Active chronic gastritis associated with Campylobacter pylori was found in three patients with portal hypertension compared with 13 patients with non-ulcer dyspepsia. The changes of reflux gastritis were seen in nine patients with portal hypertension compared with three patients with non-ulcer dyspepsia. Mucosal capillary dilatation, assessed on sections stained for factor VIII related antigen, a specific marker for endothelial cells, was significantly greater in biopsy specimens from patients with portal hypertension but this difference was not apparent on sections stained conventionally. The degree of capillary dilatation was unrelated to the presence of histological gastritis. These observations support the view that portal hypertension is associated with a distinctive gastropathy characterised by prominence and dilatation of mucosal capillaries.
为确定与门静脉高压相关的“充血性”胃病是否具有独立于炎性胃炎的独特组织学特征，对23例门静脉高压患者和25例非溃疡性消化不良患者的胃黏膜内镜活检标本进行了检查。在23例门静脉高压患者中，有3例发现与幽门弯曲菌相关的活动性慢性胃炎，而在25例非溃疡性消化不良患者中有13例发现。9例门静脉高压患者出现反流性胃炎改变，而非溃疡性消化不良患者中有3例出现。在用内皮细胞特异性标志物VIII因子相关抗原染色的切片上评估，门静脉高压患者活检标本中的黏膜毛细血管扩张明显更严重，但在常规染色切片上这种差异并不明显。毛细血管扩张程度与组织学胃炎的存在无关。这些观察结果支持以下观点，即门静脉高压与一种以黏膜毛细血管突出和扩张为特征的独特胃病相关。
