Lee Chee-Hwee, Yen Yu-Shan, Shan Yan-Shen, Lin Pin-Wen
Division of General Surgery, Department of Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Taiwan.
Department of Pathology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Taiwan.
Gastroenterology Res. 2010 Jun;3(3):139-143. doi: 10.4021/gr2010.05.206w. Epub 2010 May 20.
Follicular dendritic cells (FDC) are a subset of the immune system and present in the germinal centers of lymphoid follicles in the spleen and lymph nodes. They are functionally as antigen-presenting cells and thus improving the quality of the humoral immune response. Follicular dendritic cell tumor is rare but considered low-grade sarcoma. Including our case, there were totally 17 cases with FDC tumor involved the liver from Medline. In these cases, the mean age was 47 years old, ranged from 19 to 82. It was much more common in females than in males (13:4). The clinical manifestations of these patients included abdominal discomfort, palpable mass, weight loss and malaise. The average size of the tumor was 11 cm. Most of the FDC tumors were associated with Epstein-Barr virus expression, 13/17 (76.5%). Surgical resection remains the mainstay of the treatment.
滤泡树突状细胞（FDC）是免疫系统的一个亚群，存在于脾脏和淋巴结的淋巴滤泡生发中心。它们在功能上作为抗原呈递细胞，从而提高体液免疫反应的质量。滤泡树突状细胞瘤很罕见，但被认为是低级别肉瘤。包括我们的病例在内，医学在线数据库（Medline）中共有17例滤泡树突状细胞瘤累及肝脏。在这些病例中，平均年龄为47岁，范围从19岁至82岁。女性比男性更常见（13:4）。这些患者的临床表现包括腹部不适、可触及肿块、体重减轻和全身乏力。肿瘤的平均大小为11厘米。大多数滤泡树突状细胞瘤与爱泼斯坦-巴尔病毒表达相关，17例中有13例（76.5%）。手术切除仍然是主要的治疗方法。
