[血清磷脂酶A2免疫反应性的临床研究]

[Clinical studies of serum phospholipase A2 immunoreactivity].

作者信息

Funakoshi A, Furukawa M, Yamada Y, Wakasugi H, Abe M, Oogami Y, Shinozaki H

出版信息

Nihon Shokakibyo Gakkai Zasshi. 1989 May;86(5):1136-40.

Abstract

We tested the new radioimmunoassay method of serum phospholipase A2 (PLA2). In healthy individuals, serum PLA2 concentrations were 301 +/- 65.6 ng/dl (mean +/- SD), and in patients with acute pancreatitis, significant elevations of serum PLA2 concentrations were observed. In clinical course of acute pancreatitis, serum PLA2 was maintained high level more longer than serum amylase and elastase 1. In patients with chronic pancreatitis, serum PLA2 concentration were low at a stage of severe exocrine dysfunction, and high at a stage of acute exacerbation. In patients with pancreatic cancer, serum PLA2 concentration were changed in accord with severity of disease states. After endoscopic retrograde pancreatography, serum PLA2 levels immediately elevated significantly, and returned to basal levels 24 hours later. Serum PLA2 concentrations were within normal range in patients with other malignant tumors, diabetes mellitus, chronic liver diseases, and hypertension, whereas in patients with chronic renal failure serum PLA2 concentrations were elevated. These results suggest that measurement of serum PLA2 can be clinically useful for diagnosis of pancreatitis and monitoring of mild and severe stage of pancreatitis.

摘要

我们测试了血清磷脂酶A2（PLA2）的新型放射免疫测定方法。在健康个体中，血清PLA2浓度为301±65.6 ng/dl（均值±标准差），而在急性胰腺炎患者中，观察到血清PLA2浓度显著升高。在急性胰腺炎的临床病程中，血清PLA2维持高水平的时间比血清淀粉酶和弹性蛋白酶1更长。在慢性胰腺炎患者中，血清PLA2浓度在严重外分泌功能障碍阶段较低，而在急性加重阶段较高。在胰腺癌患者中，血清PLA2浓度随疾病状态的严重程度而变化。内镜逆行胰胆管造影术后，血清PLA2水平立即显著升高，并在24小时后恢复至基础水平。在其他恶性肿瘤、糖尿病、慢性肝病和高血压患者中，血清PLA2浓度在正常范围内，而在慢性肾衰竭患者中，血清PLA2浓度升高。这些结果表明，测定血清PLA2在临床上可用于胰腺炎的诊断以及监测胰腺炎的轻、重症阶段。