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本文引用的文献

1
Blood count parameters can predict the severity of coronary artery disease.血细胞计数参数可以预测冠状动脉疾病的严重程度。
Korean J Intern Med. 2016 Nov;31(6):1093-1100. doi: 10.3904/kjim.2015.199. Epub 2016 Apr 7.
2
Race/Ethnicity-Specific Association of Vitamin D and Global DNA Methylation: Cross-Sectional and Interventional Findings.维生素D与全基因组DNA甲基化的种族/民族特异性关联：横断面研究和干预性研究结果
PLoS One. 2016 Apr 6;11(4):e0152849. doi: 10.1371/journal.pone.0152849. eCollection 2016.
3
[Changes in 25-hydroxyvitamin D3 level and its significance in children with Kawasaki disease].[川崎病患儿25-羟维生素D3水平的变化及其意义]
Zhongguo Dang Dai Er Ke Za Zhi. 2016 Mar;18(3):211-4. doi: 10.7499/j.issn.1008-8830.2016.03.004.
4
Prediction of winter vitamin D status and requirements in the UK population based on 25(OH) vitamin D half-life and dietary intake data.
J Steroid Biochem Mol Biol. 2016 Nov;164:218-222. doi: 10.1016/j.jsbmb.2016.03.015. Epub 2016 Mar 9.
5
Adiponectin improves NF-κB-mediated inflammation and abates atherosclerosis progression in apolipoprotein E-deficient mice.脂联素可改善载脂蛋白E缺乏小鼠中核因子κB介导的炎症反应，并减缓动脉粥样硬化进程。
Lipids Health Dis. 2016 Feb 18;15:33. doi: 10.1186/s12944-016-0202-y.
6
Vitamin D improves endothelial dysfunction and restores myeloid angiogenic cell function via reduced CXCL-10 expression in systemic lupus erythematosus.维生素D可改善系统性红斑狼疮患者的内皮功能障碍，并通过降低CXCL-10表达恢复髓样血管生成细胞功能。
Sci Rep. 2016 Mar 1;6:22341. doi: 10.1038/srep22341.
7
[Role of vitamin D and calcium in obesity and type 2 diabetes].[维生素D和钙在肥胖症及2型糖尿病中的作用]
Clin Calcium. 2016 Mar;26(3):349-54.
8
Vitamin D deficiency in patients admitted to the general ward with breast, lung, and colorectal cancer in Buenos Aires, Argentina.阿根廷布宜诺斯艾利斯普通病房收治的乳腺癌、肺癌和结直肠癌患者的维生素D缺乏情况。
Arch Osteoporos. 2016;11:4. doi: 10.1007/s11657-015-0256-x. Epub 2016 Jan 5.
9
Plasma levels of monokine induced by interferon-gamma/chemokine (C-X-X motif) ligand 9, thymus and activation-regulated chemokine/chemokine (C-C motif) ligand 17 in children with Kawasaki disease.川崎病患儿血浆中γ干扰素诱导的单核细胞趋化蛋白/趋化因子（C-X-X基序）配体9、胸腺与活化调节趋化因子/趋化因子（C-C基序）配体17的水平
BMC Pediatr. 2015 Sep 3;15:109. doi: 10.1186/s12887-015-0424-6.
10
Epigenetics and Vasculitis: a Comprehensive Review.表观遗传学与血管炎：全面综述
Clin Rev Allergy Immunol. 2016 Jun;50(3):357-66. doi: 10.1007/s12016-015-8495-6.

维生素D与川崎病的关联及相关作用机制的研究进展

[Research advances in association between vitamin D and Kawasaki disease and related mechanisms of action].

作者信息

Yang Xue, Dong Xiang-Yu

机构信息

Department of Pediatrics, Lanzhou University Second Hospital, Lanzhou 730030, China.

出版信息

Zhongguo Dang Dai Er Ke Za Zhi. 2016 Dec;18(12):1319-1323. doi: 10.7499/j.issn.1008-8830.2016.12.024.

DOI:10.7499/j.issn.1008-8830.2016.12.024
PMID:27974130
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7403073/
Abstract

Vitamin D is an important steroid hormone, which has a wide biological effect and is the protective factor against cardiovascular disease and other diseases. At present, the etiology and pathogenesis of Kawasaki disease (KD) remain unknown, but recent studies have shown that vitamin D insufficiency or deficiency is associated with KD. Vitamin D insufficiency or deficiency may affect KD via its influence on inflammatory response, adipokine, endothelial function, platelet function, and DNA methylation and increase the risk of coronary artery lesions. This article reviews the research advances in the association between vitamin D and KD and possible mechanisms of action.

摘要

维生素D是一种重要的类固醇激素，具有广泛的生物学效应，是心血管疾病及其他疾病的保护因素。目前，川崎病（KD）的病因及发病机制尚不清楚，但近期研究表明，维生素D不足或缺乏与KD相关。维生素D不足或缺乏可能通过影响炎症反应、脂肪因子、内皮功能、血小板功能及DNA甲基化而影响KD，并增加冠状动脉病变的风险。本文综述维生素D与KD关联的研究进展及可能的作用机制。