Ayala Marcelo, Ntoula Evangelia
Eye Department, Skaraborg Hospital, Skövde, Sweden; Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden; Karolinska Institute, Solna, Sweden.
Eye Department, Uppsala University Hospital, Uppsala, Sweden.
J Ophthalmol. 2016;2016:4160568. doi: 10.1155/2016/4160568. Epub 2016 Nov 17.
. To evaluate the correlation between peripapillary retinal nerve fibre layer (RNFL) thickness and both age and refraction error in healthy children using optical coherence tomography (OCT). . 80 healthy children with a mean age of 9.1 years (range 3.8 to 16.7 years) undergoing routine ocular examination at the orthoptic section of the Ophthalmology Department were recruited for this cross-sectional study. After applying cycloplegia, the peripapillary RNFL thickness was measured in both eyes using the Topcon 3D OCT 2000 device. . 138 eyes were included in the analysis. The average refractive error (SE) was +1.7 D (range -5.25 to +7.25 D). The mean total RNFL thickness was 105 m ± 10.3, the mean superior RNFL thickness was 112.7 m ± 16.5, and the mean inferior RNFL thickness was 132.6 m ± 18.3. We found no statistically significant effect of age on RNFL thickness (ANOVA, = 0.33, = 0.56). Refraction was proven to have a statistically significant effect (ANOVA, = 67.1, < 0.05) in RNFL measurements. . Data obtained from this study may assist in establishing a normative database for a paediatric population. Refraction error should be taken into consideration due to its statistically significant correlation with RNFL thickness.
使用光学相干断层扫描（OCT）评估健康儿童视乳头周围视网膜神经纤维层（RNFL）厚度与年龄及屈光不正之间的相关性。 招募了80名平均年龄为9.1岁（范围3.8至16.7岁）、在眼科斜视门诊接受常规眼部检查的健康儿童进行这项横断面研究。使用托普康3D OCT 2000设备在双眼应用睫状肌麻痹后测量视乳头周围RNFL厚度。 138只眼纳入分析。平均屈光不正（SE）为+1.7D（范围-5.25至+7.25D）。平均RNFL总厚度为105μm±10.3，平均上方RNFL厚度为112.7μm±16.5，平均下方RNFL厚度为132.6μm±18.3。我们发现年龄对RNFL厚度无统计学显著影响（方差分析，F = 0.33，P = 0.56）。屈光不正被证明在RNFL测量中有统计学显著影响（方差分析，F = 67.1，P < 0.05）。 本研究获得的数据可能有助于建立儿科人群的标准数据库。由于屈光不正与RNFL厚度有统计学显著相关性，应予以考虑。
