山羊支原体的甾醇需求
Sterol requirement of Mycoplasma capricolum.
作者信息
Odriozola J M, Waitzkin E, Smith T L, Bloch K
出版信息
Proc Natl Acad Sci U S A. 1978 Sep;75(9):4107-9. doi: 10.1073/pnas.75.9.4107.
Abstract
Mycoplasmas require an external source of sterol for growth. For Mycoplasma capricolum this requirement is met not only by cholesterol but also by the methylcholestane derivatives lanosterol, cycloartenol, 4,4-dimethylcholesterol, and 4beta-methylcholestanol. Cholesteryl methyl ether and 3alpha-methylcholestanol serve equally well as sterol supplements. None of the growth-supporting sterol derivatives tested was metabolically modified. The unusual acceptance of diverse cholestane derivatives by a mycoplasma species contrasts with the structural attributes thought to be necessary for sterol function in eukaryotic membranes.
摘要
支原体生长需要外部的固醇来源。对于山羊支原体来说，不仅胆固醇能满足这一需求，甲基胆甾烷衍生物羊毛甾醇、环阿屯醇、4,4-二甲基胆固醇和4β-甲基胆甾烷醇也能满足。胆固醇甲基醚和3α-甲基胆甾烷醇作为固醇补充剂同样有效。所测试的任何一种支持生长的固醇衍生物都没有发生代谢修饰。一种支原体对多种胆甾烷衍生物的不同寻常的接受情况与真核细胞膜中固醇功能被认为必需的结构特征形成了对比。
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