Seidenberg J, Masters I B, Hudson I, Olinsky A, Phelan P D
Professorial Department of Thoracic Medicine, Royal Children's Hospital, Melbourne, Australia.
Thorax. 1989 Aug;44(8):660-7. doi: 10.1136/thx.44.8.660.
The passive flow-volume and partial forced expiratory flow-volume techniques were used to assess pulmonary function in 14 spontaneously breathing infants with acute respiratory syncytial virus bronchiolitis. Two additional infants were studied while paralysed and ventilated. During the acute stage of the illness there was a significant reduction in forced expiratory flow rates and an increase in respiratory resistance. Although the mean thoracic gas volume for the group was increased, five infants did not compensate for their airways obstruction by hyperinflation. Curvilinear passive flow-volume curves were seen in three of the 14 non-ventilated infants and in both ventilated infants. At follow up three to four months later all passive flow-volume curves were linear. There was a significant reduction in hyperinflation and an increase in forced expiratory flow rates, but values still differed significantly from those in normal infants.
采用被动流速-容量和部分用力呼气流速-容量技术，对14例急性呼吸道合胞病毒细支气管炎的自主呼吸婴儿进行肺功能评估。另外对2例婴儿在麻痹和机械通气状态下进行了研究。在疾病急性期，用力呼气流速显著降低，呼吸阻力增加。虽然该组婴儿的平均胸腔气体容量增加，但有5例婴儿未通过肺过度充气来代偿气道阻塞。14例未通气婴儿中有3例以及2例通气婴儿呈现曲线型被动流速-容量曲线。在三到四个月后的随访中，所有被动流速-容量曲线均呈线性。肺过度充气显著减轻，用力呼气流速增加，但数值仍与正常婴儿有显著差异。
