Seetharaman Sujatha, Golden Neville H, Halpern-Felsher Bonnie, Peebles Rebecka, Payne Allison, Carlson Jennifer L
Division of Adolescent Medicine, Stanford University Medical Center, Palo Alto, California.
The Craig Dalsimer Division of Adolescent Medicine, Department of Pediatrics, The Children's Hospital of Philadelphia, Perelman School of Medicine, Philadelphia, Pennsylvania.
J Adolesc Health. 2017 Apr;60(4):469-471. doi: 10.1016/j.jadohealth.2016.10.019. Epub 2016 Dec 18.
The purpose of this study was to determine whether a history of overweight, weight suppression, and weight gain during treatment have an effect on return of menses (ROM) in adolescents with eating disorders (EDs).
Retrospective chart review of female adolescents presenting to an ED program from January 2007 to June 2009.
One hundred sixty-three participants (mean age, 16.6 ± 2.1 years) met eligibility criteria. The mean median body mass index percent at ROM for those previously overweight was 106.1 ± 11.7 versus 94.2 ± 8.9 for those not previously overweight (p < .001). Both groups needed to gain weight for ROM. Greater weight suppression (odds ratio, 0.90; 95% confidence interval, 0.84-0.98; p = .013) was associated with lower likelihood of ROM, and greater weight gain during treatment (odds ratio, 1.20; 95% confidence interval, 1.07-1.36; p = .002) was associated with higher likelihood of ROM in those not previously overweight.
Previously overweight amenorrheic patients with EDs needed to be at a higher median body mass index percent for ROM compared to those who were not previously overweight.
本研究旨在确定超重史、体重抑制以及治疗期间体重增加是否会对患有饮食失调（EDs）的青少年月经恢复（ROM）产生影响。
对2007年1月至2009年6月到饮食失调项目就诊的女性青少年进行回顾性病历审查。
163名参与者（平均年龄16.6±2.1岁）符合入选标准。既往超重者月经恢复时的平均体重指数百分比中位数为106.1±11.7，而既往未超重者为94.2±8.9（p<0.001）。两组都需要增加体重才能恢复月经。更大程度的体重抑制（优势比，0.90；95%置信区间，0.84 - 0.98；p = 0.013）与月经恢复的可能性较低相关，而治疗期间体重增加更多（优势比，1.20；95%置信区间，1.07 - 1.36；p = 0.002）与既往未超重者月经恢复的可能性较高相关。
与既往未超重的闭经饮食失调患者相比，既往超重的闭经饮食失调患者月经恢复时需要更高的体重指数百分比中位数。
