Lichota Anna, Krokosz Anita
Uniwersytet Łódzki / University of Lodz, Łódź, Poland (Wydział Biologii i Ochrony Środowiska, Katedra Biofizyki Molekularnej / Faculty of Biology and Environmental Protection, Department of Molecular Biophysics).
Med Pr. 2016 Dec 22;67(6):817-831. doi: 10.13075/mp.5893.00466. Epub 2016 Nov 22.
Malignant tumors are one of the main causes of death in Poland. One of the objectives of contemporary biomedical research is to maximize the effects of therapeutic strategies. The actions undertaken to improve therapeutic agents are aimed at reducing the side effects of cancer treatments. Another direction of investigations is the search for protective substances that reduce the toxicity of the drug to normal cells. Carbon-based nanomaterials (fullerenes and their derivatives, graphene, carbon nanotubes, nanodiamonds) are a broad class of nanoparticles that have potential biomedical applications in both therapy and diagnostics. The aim of this paper is to review biological properties of fullerenols in the context of their use in various strategies of cancer treatments. The authors also discuss the possibility of simultaneous use of nanoparticles in therapy and diagnosis, that is, in theranostics. Current knowledge indicates that fullerenes and their hydrophilic derivatives, especially fullerenols, show low or no toxicity. They may contribute to the inhibition of tumor growth and protection of normal cells through their antioxidant properties, as well as to the regulation of expression of genes involved in apoptosis and angiogenesis, and stimulation of the immune response. Gadoliniumcontaining endohedral fullerenes are less toxic as a contrast agents in magnetic resonance imaging, and they may also inhibit tumor growth, which is a promising result for theranostics. Med Pr 2016;67(6):817-831.
恶性肿瘤是波兰主要的死亡原因之一。当代生物医学研究的目标之一是使治疗策略的效果最大化。为改进治疗药物所采取的行动旨在减少癌症治疗的副作用。研究的另一个方向是寻找能降低药物对正常细胞毒性的保护性物质。碳基纳米材料（富勒烯及其衍生物、石墨烯、碳纳米管、纳米金刚石）是一类广泛的纳米颗粒，在治疗和诊断方面都具有潜在的生物医学应用。本文的目的是在富勒醇用于各种癌症治疗策略的背景下，综述其生物学特性。作者还讨论了纳米颗粒在治疗和诊断中同时使用的可能性，即用于治疗诊断学。目前的知识表明，富勒烯及其亲水性衍生物，尤其是富勒醇，显示出低毒性或无毒性。它们可能通过抗氧化特性抑制肿瘤生长并保护正常细胞，还可能调节参与细胞凋亡和血管生成的基因表达，并刺激免疫反应。含钆内嵌富勒烯作为磁共振成像中的造影剂毒性较小，并且它们也可能抑制肿瘤生长，这对治疗诊断学来说是一个有前景的结果。《医学实践》2016年；67(6):817 - 831。
